推荐产品
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
25623, monoclonal
表单
lyophilized powder
种属反应性
human, rat, mouse
技术
capture ELISA: 2-8 μg/mL (detection antibody at 0.1-0.4 μg/ml)
neutralization: 0.1-0.4 μg/mL
杂质
endotoxin, tested
同位素/亚型
IgG1
UniProt登记号
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... NGF(4803)
mouse ... Ngf(18049)
免疫原
重组人NGF-β。
生化/生理作用
神经生长因子（NGF）是神经系统发育和维持所必需的生长因子。NGF由三个非共价连接的α、β和γ亚基组成。β亚基负责NGF的生物学功能。神经生长因子(NGF)与NGF受体(NGFR)或Trk受体结合，并且可以独立地通过每个受体引发生物学反应。在胚胎和出生后早期发育以及周围神经元的维持过程中，NGF在神经元和神经嵴衍生细胞的存活和分化中很重要。NGF也与炎症和过敏反应有关。
外形
从含碳水化合物的磷酸盐缓冲盐水中（经0.2 μm过滤）冻干。
制备说明
用蛋白质G纯化。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
Josemberg S Baptista et al.
PloS one, 15(1), e0228155-e0228155 (2020-01-28)
Intervertebral disc (IVD) degeneration is a remodeling process mediated by several growth factors and cytokines. This process has been extensively studied in vitro and with pathologic specimens obtained during surgery for scoliosis or back pain. However, the occurrence and temporal
Seong Hoon Seo et al.
The Journal of investigative dermatology, 140(11), 2199-2209 (2020-04-06)
Itch in atopic dermatitis (AD) is aggravated under warm conditions. Transient receptor potential vanilloid (TRPV) 3, a member of the thermosensitive transient receptor potential channels, is activated by innocuous heat and is abundantly expressed in keratinocytes. The potential role of
Wolfgang Andreas Nockher et al.
The Journal of allergy and clinical immunology, 117(3), 583-589 (2006-03-09)
Understanding the complex pathophysiology of allergic diseases has been a main challenge of clinical and experimental research for many years. It is well known that the allergic inflammation triggers neuronal dysfunction and structural changes in the diseased tissues such as
Y Indo
Clinical genetics, 82(4), 341-350 (2012-08-14)
Congenital insensitivity to pain with anhidrosis (CIPA) is an autosomal recessive genetic disorder characterized by insensitivity to pain, anhidrosis (the inability to sweat) and mental retardation. Nerve growth factor (NGF) is a well-known neurotrophic factor essential for the survival and
C D Mills et al.
European journal of pain (London, England), 17(4), 469-479 (2012-08-24)
Injection of nerve growth factor (NGF) produces mechanical and thermal hypersensitivity in rodents and humans. Treatment with sequestering antibodies demonstrates the importance of NGF in various pain states, with efficacy seen in a number of animal pain models and in
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