推荐产品
方案
≥98%
mp
291-293 °C (dec.) (lit.)
SMILES字符串
NC(=O)c1ccc[n+]([O-])c1
InChI
1S/C6H6N2O2/c7-6(9)5-2-1-3-8(10)4-5/h1-4H,(H2,7,9)
InChI key
USSFUVKEHXDAPM-UHFFFAOYSA-N
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生化/生理作用
Nicotinamide N-oxide is a niacin-related compound used in studies of mechanisms of niacin-related granulocyte differentiation of cells such as human promyelocytic leukemia cells (HL-60). Nicotinamide N-oxide reduced expression of c-myc in HL-60 cell line.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
P Dostert et al.
Xenobiotica; the fate of foreign compounds in biological systems, 15(10), 799-803 (1985-10-01)
Using the N-oxide derivative of niaprazine, a nicotinamide-based drug, as substrate, the possibility of a 1,2-oxygen shift from N to adjacent C occurring in vivo has been investigated. By comparison of the percentage of the 6-pyridone derivative formed after administration
N S Cutshall et al.
Bioorganic & medicinal chemistry letters, 11(14), 1951-1954 (2001-07-19)
A series of nicotinamide N-oxides was synthesized and shown to be novel, potent, and selective antagonists of the CXCR2 receptor. Furthermore, these compounds showed significant functional activity against GRO-alpha-driven human neutrophil chemotaxis. Compounds of this class may be useful for
Mark W Ruddock et al.
Oncology research, 16(12), 569-574 (2008-03-21)
Nicotinamide is a potent radiosensitizer currently employed in the treatment of cancer of the bladder, head, and neck. Unfortunately, nicotinamide is also a potent emetic at the concentrations required for radiosensitization. Previously, we have demonstrated that nicotinamide-induced emesis is the
K Takekawa et al.
Xenobiotica; the fate of foreign compounds in biological systems, 31(1), 11-23 (2001-05-04)
1. The mechanism of reduction of aliphatic tertiary amine N-oxides to tertiary amines in liver microsomes was examined and a novel type of reduction by cytochrome P450 was found. 2. Rat liver microsomes exhibited a significant N-oxide reductase activity toward
S Shimada et al.
Investigative ophthalmology & visual science, 28(7), 1204-1206 (1987-07-01)
The nicotinamide N-oxide reductase activity of a variety of ocular tissues was investigated. The 9,000g supernatant of ciliary body, retinal pigment epithelium-choroid, iris, retina and cornea, but not lens, exhibited reductase activity under anaerobic conditions when supplemented with 2-hydroxypyrimidine, an
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