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质量水平
方案
≥98% (HPLC)
表单
powder
颜色
red to brown
溶解性
DMSO: 5 mg/mL, clear (warmed)
储存温度
−20°C
SMILES字符串
CCOC(=O)c1ccc(cc1)N2NC(=O)\C(=C/c3ccc(o3)[N+]([O-])=O)C2=O
InChI
1S/C17H13N3O7/c1-2-26-17(23)10-3-5-11(6-4-10)19-16(22)13(15(21)18-19)9-12-7-8-14(27-12)20(24)25/h3-9H,2H2,1H3,(H,18,21)/b13-9+
InChI key
ARGIPZKQJGFSGQ-UKTHLTGXSA-N
应用
PYR-41已被用作E1抑制剂：
- 用于确定腺相关病毒（AAV）转导的细胞降解途径
- 通过基质辅助激光解吸/电离飞行时间（MALDI-TOF）E2/E3分析，评估其选择性和效力
- 处理高葡萄糖培养基中完全分化的C2C12肌管，以确定其对蛋白质泛素化和细胞活力的影响
- 预处理人脑微血管内皮细胞（hBMEC），用于细菌感染前的抑制研究
生化/生理作用
PYR-41是泛素活化酶（E1）的细胞渗透性抑制剂.
PYR-41是泛素活化酶（E1）的细胞渗透性抑制剂，对E3、E2或半胱天冬酶的活性几乎无活性或完全无活性。
PYR-41能够抑制E1泛素连接酶，如小鼠双微基因2同源物（MDM2）、痒同源物（ITCH）和HOIL-1L相互作用蛋白（HOIP）的E1泛素连接酶。 它具有潜在的抗癌作用。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Heterogeneity in pneumolysin expression governs the fate of Streptococcus pneumoniae during blood-brain barrier trafficking
Surve MV, et al.
PLoS Pathogens, 14(7), e1007168-e1007168 (2018)
Polyubiquitin Chains Linked by Lysine Residue 48 (K48) Selectively Target Oxidized Proteins In Vivo.
Sandhya Manohar et al.
Antioxidants & redox signaling, 31(15), 1133-1149 (2019-09-05)
Aims: Ubiquitin is a highly conserved protein modifier that heavily accumulates during the oxidative stress response. Here, we investigated
Implication of altered ubiquitin-proteasome system and ER stress in the muscle atrophy of diabetic rats
Reddy SS, et al.
Archives of Biochemistry and Biophysics, 639(9), 16-25 (2018)
Chun-Tao Lei et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 42(1), 281-294 (2017-05-24)
Protein Kinase C-α (PKC-α) and epidermal growth factor receptor (EGFR) are both involved in diabetic kidney disease; however, the connection between these two proteins during high glucose-induced podocyte injury remains uncertain. Diabetes was induced in SD rats by streptozotocin (STZ).
Inês B Santarino et al.
Scientific reports, 7(1), 5812-5812 (2017-07-21)
Erythrophagocytosis, the phagocytic removal of damaged red blood cells (RBC), and subsequent phagolysosome biogenesis are important processes in iron/heme metabolism and homeostasis. Phagolysosome biogenesis implies the interaction of nascent phagosomes with endocytic compartments and also autophagy effectors. Here, we report
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