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Merck
CN

N2915

Sigma-Aldrich

PYR-41

≥98% (HPLC), powder

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别名:
4-[4-[(5-硝基-2-呋喃基)亚甲基]-3,5-二氧代-1-吡唑烷基]苯甲酸乙酯
经验公式(希尔记法):
C17H13N3O7
分子量:
371.30
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

质量水平

检测方案

≥98% (HPLC)

形式

powder

颜色

red to brown

溶解性

DMSO: 5 mg/mL, clear (warmed)

储存温度

−20°C

SMILES字符串

CCOC(=O)c1ccc(cc1)N2NC(=O)\C(=C/c3ccc(o3)[N+]([O-])=O)C2=O

InChI

1S/C17H13N3O7/c1-2-26-17(23)10-3-5-11(6-4-10)19-16(22)13(15(21)18-19)9-12-7-8-14(27-12)20(24)25/h3-9H,2H2,1H3,(H,18,21)/b13-9+

InChI key

ARGIPZKQJGFSGQ-UKTHLTGXSA-N

应用

PYR-41已被用作E1抑制剂:
  • 用于确定腺相关病毒(AAV)转导的细胞降解途径
  • 通过基质辅助激光解吸/电离飞行时间(MALDI-TOF)E2/E3分析,评估其选择性和效力
  • 处理高葡萄糖培养基中完全分化的C2C12肌管,以确定其对蛋白质泛素化和细胞活力的影响
  • 预处理人脑微血管内皮细胞(hBMEC),用于细菌感染前的抑制研究

生化/生理作用

PYR-41是泛素活化酶(E1)的细胞渗透性抑制剂,对E3、E2或半胱天冬酶的活性几乎无活性或完全无活性。
PYR-41能够抑制E1泛素连接酶,如小鼠双微基因2同源物(MDM2)、痒同源物(ITCH)和HOIL-1L相互作用蛋白(HOIP)的E1泛素连接酶。 它具有潜在的抗癌作用。

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral - Skin Sens. 1

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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