推荐产品
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified from hybridoma cell culture
抗体产品类型
primary antibodies
克隆
RMdO20, monoclonal
表单
buffered aqueous solution
种属反应性
mouse, rat, human
浓度
~2 mg/mL
技术
immunocytochemistry: suitable
immunohistochemistry: suitable
microarray: suitable
western blot: 1-2 μg/mL using extracts of rat brain S1 fraction.
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... NEFH(4744) , NEFM(4741)
mouse ... Nefh(380684) , Nefm(18040)
rat ... Nefh(24587) , Nefm(24588)
一般描述
神经丝直径为10 nm，属于中间丝蛋白家族。 神经丝主要在神经元起源的细胞或组织中表达，对于轴突的适当径向生长至关重要。抗神经丝 160/200 单克隆抗体可用于 ELISA 和免疫印迹。它还可以用于微阵列。小鼠抗神经丝 160/200 抗体与小鼠、大鼠和人体内非磷酸化形式的 NF-M 和 NF-H（NF-M/H，约 160 和 200 kDa）发生特异性反应。
免疫原
纯化的中等大小大鼠神经丝 (NF-M) 亚基。
应用
单克隆抗神经丝160/200抗体可用于免疫细胞化学（1：100稀释）和蛋白质印迹（1：1,000稀释）。它还可用于免疫组织化学。
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Kim Braeckman et al.
NeuroImage. Clinical, 21, 101669-101669 (2019-01-20)
Diffusion magnetic resonance imaging biomarkers can provide quantifiable information of the brain tissue after a mild traumatic brain injury (mTBI). However, the commonly applied diffusion tensor imaging (DTI) model is not very specific to changes in the underlying cellular structures.
Sean P Murphy et al.
Journal of neurochemistry, 129(3), 509-515 (2013-10-24)
The administration of pan histone deacetylase (HDAC) inhibitors reduces ischemic damage to the CNS, both in vitro and in animal models of stroke, via mechanisms which we are beginning to understand. The acetylation of p53 is regulated by Class I
V M Lee et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 7(11), 3474-3488 (1987-11-01)
A new panel of greater than 300 monoclonal antibodies (mAbs) was prepared to the high, middle, and low Mr rat neurofilament (NF) subunits (NF-H, NF-M and NF-L, respectively). NF proteins were purified both from native, i.e., phosphorylated rat NFs and
Katherine E Brandao et al.
The Journal of comparative neurology, 520(1), 81-99 (2011-06-16)
Modulation of phosphorylation states of ion channels is a critical step in the development of hyperalgesia during inflammation. Modulatory enhancement of channel activity may increase neuronal excitability and affect downstream targets such as gene transcription. The specificity required for such
Mariangela Iovino et al.
Brain : a journal of neurology, 138(Pt 11), 3345-3359 (2015-07-30)
Tauopathies, such as Alzheimer's disease, some cases of frontotemporal dementia, corticobasal degeneration and progressive supranuclear palsy, are characterized by aggregates of the microtubule-associated protein tau, which are linked to neuronal death and disease development and can be caused by mutations
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