N2630
烟酰胺1，N6-乙烯基腺嘌呤二核苷酸
≥98%
别名:
ε-NAD, 1，N6-Etheno NAD, 1，N6-乙烯基烟酰胺腺嘌呤二核苷酸
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关于此项目
经验公式（希尔记法）:
C23H27N7O14P2
化学文摘社编号:
分子量:
687.45
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.51
生物来源
synthetic (Organic)
质量水平
方案
≥98%
表单
powder
溶解性
H2O: soluble-250 mg/mL, clear, colorless to faintly yellow
储存温度
−20°C
SMILES字符串
NC(=O)C1=CC=C[N](=C1)C2OC(COP(O)(=O)OP(O)(=O)OCC3OC(C(O)C3O)n4cnc5c4ncn6ccnc56)C(O)C2O
InChI
1S/C23H28N7O14P2/c24-19(35)11-2-1-4-28(6-11)22-17(33)15(31)12(42-22)7-40-45(36,37)44-46(38,39)41-8-13-16(32)18(34)23(43-13)30-10-26-14-20-25-3-5-29(20)9-27-21(14)30/h1-6,9-10,12-13,15-18,22-23,31-34H,7-8H2,(H2,24,35)(H,36,37)(H,38,39)
InChI key
AVLUSNAXLARRGJ-UHFFFAOYSA-N
应用
烟酰胺1,N6-乙烯基腺嘌呤二核苷酸(ε-NAD)是NAD荧光类似物（荧光团），可用于通过乙烯基-NAD+分析等方法研究ADP核糖基化反应和NAD+结合酶的结构/动力学。
其他说明
β-NAD的类似物
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
ADP-ribosylation and NAD+
Utilizing Enzymes
Utilizing Enzymes
Paul Chang
Methods in Molecular Biology, 77-90 (2018)
Hélène Muller-Steffner et al.
ACS chemical biology, 12(7), 1787-1795 (2017-05-10)
SmNACE is a NAD catabolizing enzyme expressed on the outer tegument of S. mansoni, a human parasite that is one of the major agents of the neglected tropical disease schistosomiasis. Recently, we identified aroylhydrazone derivatives capable of inhibiting the recombinant
R G Lowery et al.
The Journal of biological chemistry, 263(32), 16714-16719 (1988-11-15)
The enzyme that catalyzes the ADP-ribosylation and concomitant inactivation of dinitrogenase reductase in Rhodospirillum rubrum has been purified greater than 19,000-fold to near homogeneity. We propose dinitrogenase reductase ADP-ribosyltransferase (DRAT) as the working name for the enzyme. DRAT activity is
James N Wilson et al.
Organic & biomolecular chemistry, 4(23), 4265-4274 (2006-11-15)
We describe the design, synthesis, and properties of nucleoside monomers in which the DNA base is replaced by fluorescent hydrocarbons and heterocycles, and the assembly of these monomers into DNA-like molecules in which the all bases are fluorescent. As monomers
Y I Henis et al.
European journal of biochemistry, 112(1), 59-73 (1980-11-01)
The binding of nicotinamide--adenine dinucleotide (NAD+), nicotinamide--1,N6-ethenoadenine dinucleotide (epsilon NAD+), acetylpyridine--adenine dinucleotide (AcPyAD+), ATP, and adenosine diphosphoribose (ADP-ribose) to rabbit muscle glyceraldehyde-3-phosphate dehydrogenase (the enzyme) was examined. NAD+ and epsilon NAD+ were found to bind to the apoenzyme in a
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