一般描述
NGFβ（神经生长因子β）是一种参与信号转导的蛋白质，表达于多种组织中，如胎盘、尿路上皮和膀胱平滑肌细胞。它是一种神经营养因子，属于NGF家族。
应用
大鼠NGF-β被用于以下应用：
- 制备DMEM培养基（用于PC12细胞的培养和分化）
- 蛋白质免疫印迹分析
- 制备分化培养基（采用DMEM制备，NGF-β是其中一种成分）
- 细胞培养和处理（用于神经元分化）
- 制备储液
生化/生理作用
NGFβ（神经生长因子β）对神经元的分化和存活至关重要。它在神经系统的发育和维持中也具有关键作用。它还参与血管生成，并促进肿瘤发生，如口腔癌、乳腺癌和前列腺癌。它是用于诊断间质性膀胱炎/膀胱疼痛综合征（IC/PBS）和膀胱过度活动症（OAB）的潜在标记物，还可能有助于决定这些疾病的治疗方法。它可能与胎盘功能的变化有关，因为NGF信号传导受到产前抑郁和选择性血清素再摄取抑制剂（SSRI）治疗的影响。
外形
本品是从0.2 μm过滤溶液中冻干的，溶剂为PBS和1M NaCl，含有50 μg牛血清白蛋白/1 μg细胞因子
分析说明
使用因子依赖性人红白血病细胞系TF-1，在细胞增殖测定中测定生物活性。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
含少量动物源组分生物产品
常规特殊物品
Guangyi Zhao et al.
Molecular medicine reports, 16(4), 4678-4684 (2017-08-30)
The present study aimed to investigate the effect of exogenous nerve growth factor (NGF) pretreatment on demyelination in the spinal cord of lidocaine‑treated rats, and explored the potential neuroprotective mechanisms of NGF. A total of 36 rats were randomly assigned
Xiao-Ping Huang et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 89, 124-134 (2017-02-22)
The aim of this study was to explore the effect by which the combination of Astragaloside IV (AST IV) and Ginsenoside Rg1 (Rg1) resisted autophagic injury in PC12 cells induced by oxygen glucose deprivation/reoxygenation (OGD/R). We studied the nature of
A Khodorova et al.
Neuroscience, 254, 312-323 (2013-10-08)
Nerve growth factor (NGF) augments the excitability of isolated rat sensory neurons through activation of the p75 neurotrophin receptor (p75(NTR)) and its downstream sphingomyelin signaling cascade, wherein neutral sphingomyelinase(s) (nSMase), ceramide, and the atypical protein-kinase C (aPKC), protein-kinase M zeta
Zhe Gong et al.
Journal of neuroinflammation, 15(1), 242-242 (2018-08-30)
Nod-like receptor protein 3 (NLRP3) inflammasome is a crucial factor in mediating inflammatory responses after cerebral ischemia/reperfusion (I/R), but the cellular location of NLRP3 inflammasome in cerebral I/R has yet come to a conclusion, and there is still no specific
Saar Oz et al.
PloS one, 7(12), e51458-e51458 (2012-12-29)
Microtubules (MTs), key cytoskeletal elements in living cells, are critical for axonal transport, synaptic transmission, and maintenance of neuronal morphology. NAP (NAPVSIPQ) is a neuroprotective peptide derived from the essential activity-dependent neuroprotective protein (ADNP). In Alzheimer's disease models, NAP protects
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