所有图片(1)
About This Item
经验公式（希尔记法）:
C22H34N4O · 3HCl
CAS号:
分子量:
479.91
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
方案
≥95% (HPLC)
质量水平
表单
powder
储存条件
desiccated
protect from light
颜色
white
溶解性
H2O: ≥20 mg/mL
SMILES字符串
Cl.Cl.Cl.NCCCNCCCCNCCCNC(=O)Cc1cccc2ccccc12
InChI
1S/C22H34N4O.3ClH/c23-12-6-15-24-13-3-4-14-25-16-7-17-26-22(27)18-20-10-5-9-19-8-1-2-11-21(19)20;;;/h1-2,5,8-11,24-25H,3-4,6-7,12-18,23H2,(H,26,27);3*1H
InChI key
JNEOJAUJWOPWJS-UHFFFAOYSA-N
应用
1-Naphthylacetyl spermine trihydrochloride has been used for the inhibition of calcium-permeable AMPAR (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor). It has also been used to study the involvement of AMPAR in biphasic activation of stress-activated protein kinase/extracellular signal-regulated kinase-1.
生化/生理作用
Blocks Ca2+ permeable AMPA receptor channels.
其他说明
Synthetic analog of Joro spider toxin.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
K Oguro et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 19(21), 9218-9227 (1999-10-26)
Considerable evidence suggests that Ca(2+)-permeable AMPA receptors are critical mediators of the delayed, selective neuronal death associated with transient global ischemia and sustained seizures. Global ischemia suppresses mRNA and protein expression of the glutamate receptor subunit GluR2 and increases AMPA
beta-Adrenergic receptors regulate the acquisition and consolidation phases of aversive memory formation through distinct, temporally regulated signaling pathways
Schiff HC, et al.
Neuropsychopharmacology, 42(4), 895-895 (2017)
Cornelia Strobel et al.
The Journal of physiology, 595(16), 5653-5669 (2017-06-09)
Dendritic and spine calcium imaging in combination with electrophysiology in acute slices revealed that in medial intercalated cells of the amygdala: Action potentials back-propagate into the dendritic tree, but due to the presence of voltage-dependent potassium channels, probably Kv4.2 channels
Blocking effect of 1-naphthyl acetyl spermine on Ca2+--p-ermeable AMPA receptors in cultured rat hippocampal neurons.
Koiki, M., et al.
Journal of Neuroscience Research, 29, 27-36 (1997)
H Tsubokawa et al.
Journal of neurophysiology, 74(1), 218-225 (1995-07-01)
1. We studied the effects of polyamine toxins derived from a spider venom on CA1 pyramidal neurons in gerbil hippocampal slices by patch-clamp recording. Joro spider toxin (JSTX) and its synthetic analogue, 1-naphthyl acetyl spermine (Naspm), which are known to
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门