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N193

1-Naphthylacetyl spermine trihydrochloride

Name: 1-Naphthylacetyl spermine trihydrochloride
Brand: SIGMA

≥95% (HPLC), Ca2+ permeable AMPA receptor channel blocker, powder

别名:

NASPM trihydrochloride

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关于此项目

经验公式（希尔记法）:

C₂₂H₃₄N₄O · 3HCl

化学文摘社编号:

1049731-36-3

分子量:

479.91

UNSPSC Code:

12352200

PubChem Substance ID:

24897539

NACRES:

NA.77

MDL number:

MFCD01321052

Assay:

≥95% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated, protect from light

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属性

产品名称

1-Naphthylacetyl spermine trihydrochloride,

assay

≥95% (HPLC)

Quality Level

100

form

powder

storage condition

desiccated, protect from light

color

white

solubility

H₂O: ≥20 mg/mL

SMILES string

Cl.Cl.Cl.NCCCNCCCCNCCCNC(=O)Cc1cccc2ccccc12

InChI

1S/C22H34N4O.3ClH/c23-12-6-15-24-13-3-4-14-25-16-7-17-26-22(27)18-20-10-5-9-19-8-1-2-11-21(19)20;;;/h1-2,5,8-11,24-25H,3-4,6-7,12-18,23H2,(H,26,27);3*1H

InChI key

JNEOJAUJWOPWJS-UHFFFAOYSA-N

说明

Application

1-Naphthylacetyl spermine trihydrochloride has been used for the inhibition of calcium-permeable AMPAR (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor). It has also been used to study the involvement of AMPAR in biphasic activation of stress-activated protein kinase/extracellular signal-regulated kinase-1.

Biochem/physiol Actions

Blocks Ca²⁺ permeable AMPA receptor channels.

Other Notes

Synthetic analog of Joro spider toxin.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Potent and long-lasting anticonvulsant effects of 1-naphthylacetyl spermine, an analogue of Joro spider toxin, against amygdaloid kindled seizures in rats.

A Takazawa et al.

Brain research, 706(1), 173-176 (1996-01-08)

The anticonvulsant effect of 1-naphthylacetyl spermine (1-NA-Spm), an analogue of Joro spider toxin, against amygdaloid kindled seizures was studied in rats. 1-NA-Spm (10, 20 and 40 micrograms/rat) dose-dependently improved kindled seizures and shortened the afterdischarge duration 30 min after the

Effects of a spider toxin and its analogue on glutamate-activated currents in the hippocampal CA1 neuron after ischemia.

H Tsubokawa et al.

Journal of neurophysiology, 74(1), 218-225 (1995-07-01)

1. We studied the effects of polyamine toxins derived from a spider venom on CA1 pyramidal neurons in gerbil hippocampal slices by patch-clamp recording. Joro spider toxin (JSTX) and its synthetic analogue, 1-naphthyl acetyl spermine (Naspm), which are known to

Drosophila motor neuron boutons remodel through membrane blebbing coupled with muscle contraction.

Fernandes, et al.

Nature Communications, 14, 3352-3352 (2023)

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全球贸易项目编号

货号	GTIN
N193-5MG	04061832092270
N193-25MG	04061832083353