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Merck
CN

N1628

新生霉素 钠盐

≥90% (HPLC)

别名:

Albamycin, Albamycin Sodium, Cathomycin sodium

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关于此项目

经验公式（希尔记法）:
C31H35N2NaO11
化学文摘社编号:
1476-53-5
分子量:
634.61
NACRES:
NA.85
PubChem Substance ID:
24897508
UNSPSC Code:
51286504
EC Number:
216-023-6
Beilstein/REAXYS Number:
3892910

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产品名称

新生霉素 钠盐, ≥90% (HPLC)

InChI key

AXOUUAINTJNFRS-UHFFFAOYSA-N

InChI

1S/C31H35N2O11.Na/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29;/h7,9-13,23,25-26,29,34,36H,8H2,1-6H3,(H2,32,39)(H,33,37);/q-1;+1

SMILES string

[Na+].CO[C@@H]1[C@@H](OC(N)=O)[C@@H](O)[C@H](Oc2ccc3C([O-])=C(NC(=O)c4ccc(O)c(C\C=C(\C)C)c4)C(=O)Oc3c2C)OC1(C)C

biological source

(STREPTOMYCES NIVEUS)

assay

≥90% (HPLC)

form

powder

storage condition

(Tightly closed. Dry. )

color

white to yellow

antibiotic activity spectrum

Gram-positive bacteria

mode of action

DNA synthesis | interferes
enzyme | inhibits

storage temp.

2-8°C

Quality Level

200

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相关类别

Application

For the production of positively supercoiled plasmid DNA. Inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Inhibitor of retrovirus RNA-dependent DNA-polymerase.
Novobiocin Sodium Salt, an inhibitor of Hsp90, can be used:
  • in the research heat shock protein inhibition and to produce positively supercoiled plasmid DNA
  • in the research on the efficacy of probiotics
  • in the research on the efficacy of human monocytes and dendritic cells for T-cell replication

Biochem/physiol Actions

Mode of Action: Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II.
Antimicrobial spectrum: Gram-positive bacterial.
Novobiocin inhibits DNA synthesis by inhibiting the GyrB subunit of the Topoisomerase enzyme involved in energy transduction. Novobiocin acts as a competitive inhibitor of the ATPase reaction catalysed by GyrB.

Features and Benefits

High quality antibiotic suitable for mulitple research applications

General description

Novobiocin sodium salt is an antibiotic derived from soil bacteria. Novobiocin inhibits the action of bacterial DNA gyrase and belongs to a class of compounds called coumarin antibiotics. Coumarins are heterocyclic compounds with a wide range of biological activity, including antibacterial, anticoagulant, antioxidant, anti-inflammatory, antiviral, antitumor, and enzyme inhibitory effects.

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Preparation Note

Stored in frozen aliquots, Keep container tightly closed in a dry and well-ventilated place. Light sensitive

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000484178
0000484178
0000485814
0000485814
0000480155

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Temporal effects of lactic acid bacteria probiotic culture on Salmonella in neonatal broilers
Higgins et al.
Poultry Science, Aug;86(8):, 1662-1666 (2007)
Evaluation of a Lactobacillus-based probiotic culture for the reduction of Salmonella enteritidis in neonatal broiler chicks
Higgins et al.
Poultry Science, 87, 27-31 (2008)
Relative efficacy of human monocytes and dendritic cells as accessory cells for T cell replication
Voorhis et al.
The Journal of Experimental Medicine, 58, 174-191 (1983)
A Maxwell
Molecular microbiology, 9(4), 681-686 (1993-08-01)
The coumarin group of antibiotics have as their target the bacterial enzyme DNA gyrase. The drugs bind to the B subunit of gyrase and inhibit DNA supercoiling by blocking the ATPase activity. Recent data show that the binding site for
Yosef D Huberman et al.
Poultry science, 98(6), 2422-2431 (2019-01-29)
Salmonellosis caused by Salmonella Enteritidis is a widespread zoonosis and poultry products are an important source of infection. This study was carried out to evaluate the protection of different vaccination schedules in layers using a live commercial attenuated Salmonella Enteritidis
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