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质量水平
检测方案
≥98% (HPLC)
形式
solid
颜色
tan
溶解性
DMSO: soluble 3 mg/mL at 60 °C
H2O: insoluble
运输
wet ice
储存温度
2-8°C
SMILES字符串
O=C1C=C(Oc2c1ccc3ccccc23)N4CCOCC4
InChI
1S/C17H15NO3/c19-15-11-16(18-7-9-20-10-8-18)21-17-13-4-2-1-3-12(13)5-6-14(15)17/h1-6,11H,7-10H2
InChI key
KKTZALUTXUZPSN-UHFFFAOYSA-N
应用
NU7026 已用于：
- 作为 DNA 依赖性蛋白激酶（DNA-PK）抑制剂，用于治疗结肠癌细胞
- 在激酶抑制剂实验中，用于处理在 20 h-人绒毛膜促性腺激素（hCG）后原核可见的受精卵
- 确定其对 dibenzo[def,p]chrysene 处理 HepG2 细胞的细胞毒性的影响
有效的，ATP 竞争。IC50 = 0.23 μM。对其他 PI3K 相关激酶的选择性（对于 PI3K，IC50 = 13 μM，对于 ATM 和 ATR 为 >100 μM）。
生化/生理作用
细胞可透过性 DNA-PK（DNA 依赖性蛋白激酶）小分子 benzochromenone 抑制剂。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Soichiro Shiga et al.
Biochemical and biophysical research communications, 521(3), 668-673 (2019-11-05)
Presence of unperfused regions containing cells under hypoxia and nutrient starvation; contributes to radioresistance in solid human tumors. We have previously reported that cultured cells; under nutrient starvation show resistance to ionizing radiation compare with cells under normal; condition, and
Hideaki Ogiwara et al.
PloS one, 6(12), e28756-e28756 (2011-12-24)
Non-homologous end joining (NHEJ) is a major pathway for the repair of DNA double strand break (DSBs) with incompatible DNA ends, which are often generated by ionizing irradiation. In vitro reconstitution studies have indicated that NHEJ of incompatible DNA ends
Rachel E Doherty et al.
Cancers, 11(9) (2019-09-05)
Uveal melanoma (UM) is the most common primary intraocular tumour in adults, with a mean survival of six months following metastasis. The survival rates have not improved in over 30 years. This study has shown that sister chromatid exchange (SCE)
Takeshi Yasuda et al.
Genes to cells : devoted to molecular & cellular mechanisms, 26(5), 328-335 (2021-02-25)
SIRT2 and SIRT3 protein deacetylases maintain genome integrity and stability. However, their mechanisms for maintaining the genome remain unclear. To examine the roles of SIRT2 and SIRT3 in DSB repair, I-SceI-based GFP reporter assays for HR, single-strand annealing (SSA) and
The influence of ATM, ATR, DNA-PK inhibitors on the cytotoxic and genotoxic effects of dibenzo [def, p] chrysene on human hepatocellular cancer cell line HepG2
Spryszynska S, et al.
Mutation Research. Genetic Toxicology and Environmental Mutagenesis, 791, 12-24 (2015)
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