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安全信息

N1517

Sigma-Aldrich

N-亚硝基-N-甲基脲

ISOPAC®

别名:

MNU, N-甲基-N-亚硝基脲

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About This Item

经验公式（希尔记法）:
C2H5N3O2
CAS号:
684-93-5
分子量:
103.08
MDL编号:
MFCD00014794
UNSPSC代码:
12352200
PubChem化学物质编号:
24897498

储存温度

2-8°C

SMILES字符串

CN(N=O)C(N)=O

InChI

1S/C2H5N3O2/c1-5(4-7)2(3)6/h1H3,(H2,3,6)

InChI key

ZRKWMRDKSOPRRS-UHFFFAOYSA-N

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生化/生理作用

一种在许多动物物种中具有致癌性的DNA烷基化剂。 尽管MNU可以在大多数器官中诱发良性和恶性肿瘤，但它最常用于模拟乳腺肿瘤的发生和发展。

包装

100 mL血清瓶封装，配有丁基橡胶塞和铝质撕裂密封。

注意

将任何相容溶剂直接注入小瓶中，可制备任何所需规格的溶液，无需暴露。

重悬

将内容物溶解在100mL溶剂中，可得到1％的溶液。

法律信息

Isopac is a registered trademark of Merck KGaA, Darmstadt, Germany

ISOPAC

产品编号
说明
价格

警示用语：

Danger

危险分类

Acute Tox. 3 Oral - Carc. 1B - Flam. Sol. 2 - Repr. 1B

储存分类代码

4.1B - Flammable solid hazardous materials

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges, type P3 (EN 143) respirator cartridges

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKBQ7120V
SLBH1819V
SLBF6813V
SLBC9358V
SLBC2876V

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is the purity of N-Nitroso-N-methylurea - ISOPAC®, Product N1517?

    Product No. N1517 is not assayed for purity.

  4. Is N-Nitroso-N-methylurea - ISOPAC®, Product N1517, hazardous material?

    Yes, N-Nitroso-N-methylurea (MNU) is extremely hazardous. It is a known carcinogen. N1517 is packaged as an ISOPAC so that the material does not need to weighed out. Any precautions that one can take to minimize handling the material would be advisable.

  5. What is N-Nitroso-N-methylurea - ISOPAC®, Product N1517, soluble in?

    Dissolving the contents in 100 mL of solvent yields a 1% solution. We would recommend using either ethanol or DMSO as the solvent. MNU has very poor stability in aqueous solutions.

  6. The package size of N-Nitroso-N-methylurea - ISOPAC®, Product N1517, is 1 gram (N1517-1G), but I see that this product also contains acetic acid and water. How much of each is in the bottle?

    Each bottle contains 1 gram of MNU. There is a significant amount of acetic acid and water present; the specific quantities are given on the certificate of analysis of each lot. Including the acetic acid and water, the total amount of material in each bottle will typically be in the 1-2 gram range.

  7. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  8. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Yuan-Yuan Chen et al.
Experimental eye research, 121, 102-113 (2014-02-11)
Mouse retinal degeneration models have been investigated for many years in the hope of understanding the mechanism of photoreceptor cell death. N -methyl- N -nitrosourea (MNU) has been previously shown to induce outer retinal degeneration in mice. After MNU was
Marzena Kurowska et al.
Mutation research, 738-739, 52-70 (2012-10-23)
We present studies aimed at determining the types and frequencies of mutations induced in the barley genome after treatment with chemical (N-methyl-N-nitrosourea, MNU) and physical (gamma rays) mutagens. We created M(2) populations of a doubled haploid line and used them
Alice A Ramos et al.
Journal of toxicology and environmental health. Part A, 75(13-15), 765-775 (2012-07-14)
DNA damage induced by oxidative and alkylating agents contributes to carcinogenesis, leading to possible mutations if replication proceeds without proper repair. However, some alkylating agents are used in cancer therapy due to their ability to induce DNA damage and subsequently
Kawiya Sintara et al.
Journal of biomedicine & biotechnology, 2012, 915380-915380 (2012-06-13)
To determine effects of curcumin on N-methyl-N-nitrosourea (MNU) and saturated sodium chloride (s-NaCl)-induced gastric cancer in rats. Male Wistar rats were divided into 5 groups: control (CO), control supplemented with 200 mg/kg curcumin (CC), MNU + s-NaCl, MNU + s-NaCl supplemented with 200 mg/kg curcumin daily
Yong Soon Chun et al.
Carcinogenesis, 33(11), 2242-2249 (2012-07-27)
Multiple lines of evidence support a role for curcumin in cancer chemoprevention. Nonetheless, despite its reported efficacy and safety profile, clinical translation of curcumin has been hampered by low oral bioavailability, requiring infeasible 'mega' doses for achieving detectable tissue levels.
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