N151
Nisoxetine hydrochloride
≥98% (HPLC), Norepinephrine reuptake inhibitor, solid
别名:
(±)-γ-(2-Methoxyphenoxy)-N-methyl-benzenepropanamine hydrochloride, LY-94,939
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C17H21NO2 · HCl
化学文摘社编号:
分子量:
307.82
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Nisoxetine hydrochloride, solid, ≥98% (HPLC)
SMILES string
Cl[H].CNCCC(Oc1ccccc1OC)c2ccccc2
InChI key
LCEURBZEQJZUPV-UHFFFAOYSA-N
InChI
1S/C17H21NO2.ClH/c1-18-13-12-15(14-8-4-3-5-9-14)20-17-11-7-6-10-16(17)19-2;/h3-11,15,18H,12-13H2,1-2H3;1H
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
color
white to beige
solubility
H2O: 20 mg/mL, ethanol: 50 mg/mL
Quality Level
Application
Nisoxetine has been used as a norepinephrine transport (NET) blocker in autoradiography studies. It has also been used as a NET blocker to study its effects on perivascular adipose tissue.
Biochem/physiol Actions
Nisoxetine is a selective and potent noradrenaline reuptake inhibitor. It has a high affinity towards the noradrenaline transporter. Nisoxetine possesses antidepressant activity.
Features and Benefits
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Adjmal Nahimi et al.
International review of neurobiology, 141, 251-274 (2018-10-14)
Noradrenergic neurons in both the peripheral nervous system and in the central nervous system (CNS) undergo severe degeneration in patients with Parkinson's disease (PD). This loss of noradrenaline may play essential roles in the occurrence of a wide range of
S M Tejani-Butt et al.
European journal of pharmacology, 191(2), 239-243 (1990-11-27)
[3H]Nisoxetine binds with high affinity (Kd = 0.7 nM) and selectivity to a homogenous population of sites associated with the uptake of norepinephrine. Specific [3H]nisoxetine binding to rat cortical homogenates was saturable, sodium-dependent and averaged 90% of total binding at
Jacob P R Jacobsen et al.
Psychopharmacology, 199(2), 137-150 (2008-05-23)
Exploring differences between mouse strains in drug effects in models of antidepressant-like activity may provide clues to the neurobiology of antidepressant responses. The objective of this study was to explore whether insensitivity to selective serotonin reuptake inhibitors (SSRIs) in NMRI
B E Leonard
Neurochemistry international, 4(5), 339-350 (1982-01-01)
An attempt has been made to assess critically the clinical and experimental evidence that implicates a malfunctioning of amine neurotransmitter systems in the aetiology of depression. The evidence available does provide indirect evidence in favour of the biogenic amine theory
Dagmar E Ettlinger et al.
Nuclear medicine and biology, 35(4), 475-479 (2008-05-17)
Since the late 1980s, cocaine analogues based on the phenyltropane structure, such as [(11)C]CFT and [(123)I]beta-CIT have been used for the imaging of the dopamine transporter. FE@CIT (fluoropropyl ester) and FP-CIT (N-fluoropropyl derivative) are further analogues. The aim of this
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持