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产品名称
NGF-β human, from human, recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture
生物来源
human
质量水平
重组
expressed in NSO cells
方案
>97% (SDS-PAGE)
表单
lyophilized powder
效能
0.15-3.0 ng/mL ED50/EC50
质量
endotoxin tested
包装
pkg of 5X0.1 mg
pkg of 0.1 mg
技术
cell culture | mammalian: suitable
杂质
<1 EU/μg
溶解性
water: soluble 0.1 g/L at 20 °C
UniProt登记号
储存温度
−20°C
基因信息
human ... NGF(4803)
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一般描述
The nerve growth factor β (NGFB) gene is mapped to human chromosome 1p13.2.
应用
NGF-β human has been used:
- in protein pin arrays
- to induce U87-MG (glioblastoma cell line) cell proliferation
- in drug release kinetics
生化/生理作用
Nerve growth factor β (NGFB) acts as a key mediator in neuronal and non-neuronal development, differentiation, and survival. Polymorphism of NGFB gene leads to hereditary sensory and autonomic neuropathies. Charcot arthropathy and thermal insensitivity are few of the related symptoms. NGFβ is known to promote cancer cell proliferation and metastasis, also mediates angiogenesis. It facilitates the development of various cancer including, oral, breast, lungs, pancreatic and prostate cancers. Elevated expression of NGFβ contributes to progression of human cholangiocarcinoma. In animal models, NGFβ is observed to prevent cholinergic neuron loss and enhances memory. NGF-β promotes the survival and cholinergic phenotype of basal forebrain cholinergic neurons and stimulates neurite outgrowth of embryonic trigeminal motor neurons in vitro.
外形
Lyophilized from 0.2% acetic acid containing 5 mg bovine serum albumin.
分析说明
The biological activity is measured in a cell proliferation assay using a factor-dependent human erythroleukemic cell line, TF-1.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
K A Crutcher et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 13(6), 2540-2550 (1993-06-01)
A two-site ELISA and a bioassay were used to detect NGF-like activity in human brain tissue. Both assays detected mouse NGF and recombinant human NGF with approximately equal sensitivity, whereas the antibodies showed little cross-reactivity with the recombinant human proteins
S Korsching
The Journal of neuroscience : the official journal of the Society for Neuroscience, 13(7), 2739-2748 (1993-07-01)
The neurotrophic factor concept in its basic form envisages that innervated tissues produce a signal for the innervating neurons for the selective limitation of neuronal death occurring during development (Purves, 1986; Oppenheim, 1991). This concept arose several decades ago on
Mahmoud Aarabi et al.
Fertility and sterility, 102(2), 440-447 (2014-06-09)
To determine the levels of postacrosomal WW binding protein (PAWP) in the spermatozoa of men that were used clinically for intracytoplasmic sperm injection (ICSI) and to correlate them with infertility treatment outcomes. Prospective clinical and laboratory study. University-based laboratory and
A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease
Tuszynski MH, et al.
Nature Medicine, 11(5), 551-551 (2005)
Expression of NGF, GDNF and MMP-9 in prostate carcinoma
Baspinar S, et al.
Pathology, research and practice, 213(5), 483-489 (2017)
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