推荐产品
质量水平
检测方案
≥98% (HPLC)
形式
solid
药品控制
regulated under CDSA - not available from Sigma-Aldrich Canada
颜色
white to tan
溶解性
H2O: >10 mg/mL
储存温度
2-8°C
SMILES字符串
[I-].[H][C@]12Oc3c(O)ccc4C[C@@H]5[C@](O)(CCC1=O)[C@@]2(CC[N@+]5(C)CC=C)c34
InChI
1S/C20H23NO4.HI/c1-3-9-21(2)10-8-19-16-12-4-5-13(22)17(16)25-18(19)14(23)6-7-20(19,24)15(21)11-12;/h3-5,15,18,24H,1,6-11H2,2H3;1H/t15-,18+,19+,20-,21?;/m1./s1
InChI key
ICONPJDAXITIPI-UXYWFNEESA-N
应用
Naloxone methiodide has been used as inhibitor of opioid receptor in fish and mice. Naloxone methiodide has been used to block opioid neurotransmission.
生化/生理作用
Naloxone methiodide has low affinity for opioid receptors than naloxone. Administration of naloxone inhibits opioid receptor and opioid-induced respiratory depression.
Quaternary salt of naloxone that, like the parent compound, is a nonselective antagonist at opioid receptors. It does not cross the blood-brain barrier.
警示用语:
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
European journal of pharmacology, 885, 173514-173514 (2020-08-30)
PK20M (Dmt-D-Lys-Phe-Phe-OH) is a novel modified endomorphin-2 (EM-2) peptide producing strong dose- and time-dependent antinociceptive activity. Yet its prototype, endogenous EM-2, has been reported to trigger respiratory and vascular effects such as apnea and hypotension. The purpose of this study
Delta opioid receptors are essential to the antiallodynic action of Β2-mimetics in a model of neuropathic pain.
Molecular pain, 16, 1744806920912931-1744806920912931 (2020-03-27)
Scientific reports, 8(1), 15551-15551 (2018-10-21)
Opioids remain the gold standard for the treatment of moderate to severe pain. However, their analgesic properties come with important side effects, including pruritus, which occurs frequently after systemic or neuraxial administration. Although part of the opioid-induced itch is mediated
Naloxone and its quaternary derivative, naloxone methiodide, have differing affinities for mu, delta, and kappa opioid receptors in mouse brain homogenates
Brain Research, 964(2), 302 -3305 (2003)
Naloxone methiodide reverses opioid-induced respiratory depression and analgesia without withdrawal
European Journal of Pharmacology, 445(1-2), 61 -667 (2002)
我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门