N1141
19-Nor-4-androstene-3,17-dione
别名:
4-Estrene-3,17-dione
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关于此项目
经验公式（希尔记法）:
C18H24O2
化学文摘社编号:
分子量:
272.38
UNSPSC Code:
41116107
PubChem Substance ID:
EC Number:
211-995-8
MDL number:
InChI key
JRIZOGLBRPZBLQ-QXUSFIETSA-N
InChI
1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h10,13-16H,2-9H2,1H3/t13-,14+,15+,16-,18-/m0/s1
SMILES string
C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@H]34)[C@@H]1CCC2=O
drug control
USDEA Schedule IIIN; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
format
neat
storage temp.
room temp
General description
19-Nor-4-androstene-3,17-dione is an anabolic steroid used in dietary food supplements.
Application
19-Nor-4-androstene-3,17-dione may be used as a reference standard in the determination of 19-nor-4-androstene-3,17-dione in dietary supplements using liquid chromatography coupled with tandem mass spectrometry (LC-MS-MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
法规信息
新产品
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Alberto Cassetta et al.
The Journal of steroid biochemistry and molecular biology, 171, 80-93 (2017-03-06)
Phytoestrogens are plant-derived compounds that functionally and structurally mimic mammalian estrogens. Phytoestrogens have broad inhibitory activities toward several steroidogenic enzymes, such as the 17β-hydroxysteroid dehydrogenases (17β-HSDs), which modulate the biological potency of androgens and estrogens in mammals. However, to date
D H Catlin et al.
JAMA, 284(20), 2618-2621 (2000-11-22)
Several anabolic steroids are sold over-the-counter (OTC) in the United States, and their production is not regulated by the US Food and Drug Administration. Reports have suggested that use of these supplements can cause positive urine test results for metabolites
Phillip Watson et al.
Medicine and science in sports and exercise, 41(4), 766-772 (2009-03-12)
Quantities of various anabolic/androgenic steroids have been found in dietary supplements without their presence being disclosed on the label. The aim of this study was to quantify the excretion patterns of the diagnostic metabolites, 19-norandrosterone (19-NA), and 19-noretiocholanolone (19-NE) after
Determination of anabolic steroids in dietary supplements by liquid chromatography?tandem mass spectrometry.
Poucke V C, et al.
Analytica Chimica Acta, 586(1-2), 35-42 (2007)
Mario Thevis et al.
Therapeutic drug monitoring, 29(2), 236-247 (2007-04-10)
5alpha-Reductase inhibitors such as finasteride are prohibited in sports according to the World Anti-Doping Agency. This class of drugs is used therapeutically to treat benign prostatic hyperplasia, as well as male baldness, by decreasing 5alpha-reductase activity. Accordingly, metabolic pathways of
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