所有图片(1)
About This Item
经验公式（希尔记法）:
C10H14N2
CAS号:
分子量:
162.23
Beilstein:
82108
MDL编号:
UNSPSC代码:
12352210
eCl@ss:
39151701
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
质量水平
方案
≥99% (TLC)
表单
liquid
旋光性
[α]25/D 0°(lit.)
颜色
yellow
溶解性
ethanol: 50 mg/mL
密度
1.02 g/mL at 25 °C (lit.)
SMILES字符串
CN1CCCC1c2cccnc2
InChI
1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3
InChI key
SNICXCGAKADSCV-UHFFFAOYSA-N
基因信息
human ... CHRNA2(1135) , CHRNA3(1136) , CHRNA4(1137)
rat ... Chrna3(25101) , Chrna4(25590) , Chrna7(25302)
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应用
(±)-Nicotine has been used:
- as a supplement of high-glucose Dulbecco′s modified Eagle′s medium, to test its effect on mesenchymal stem cells
- as a standard for the determination of nicotine concentration using phase high-pressure liquid chromatography
- as a test compound to study its effects on fibril formation
生化/生理作用
(±)-Nicotine is a tertiary amine compound that is predominantly present in tobacco. It binds to the nicotinic cholinergic receptors of the brain, autonomic ganglia and neuromuscular junction. Nicotine allosterically regulates a number of biological events such as production of growth hormone, dopamine, adrenocorticotropic hormone and prolactin. Nicotine absorption across biological membranes is pH sensitive, which alters its ionization state. Absorption of nicotine is shown to be higher at alkaline pH, when it remains unionized. Nicotine metabolism occurs extensively in the liver and it can cross placenta.
Prototype nicotinic acetylcholine receptor agonist.
包装
The material is liquid, transparent, and viscous, packaged in amber vail, and the volume inserted into each bottle is very small, It may form a thin FILM on the sides. While it may be difficult to see the material inside by the eyes, the container is not empty.
警示用语：
Danger
危险分类
Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
213.8 °F - closed cup
闪点(°C)
101 °C - closed cup
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
监管及禁止进口产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Alterations in the production and concentration of selected alkaloids as a function of rising atmospheric carbon dioxide and air temperature: implications for ethno-pharmacology
Ziska LH, et al.
Global Change Biology, 11(10), 1798-1807 (2005)
Neal L Benowitz
Nicotine Safety and Toxicity, 3-7 (1998)
Guangxin Luan et al.
Experimental and therapeutic medicine, 23(1), 11-11 (2021-11-25)
Pulmonary emphysema is one of the most important pathological manifestations of chronic obstructive pulmonary disease and is commonly associated with cigarette smoking. Previous studies have indicated that necroptosis, a novel non-apoptotic cell death mechanism associated with inflammation and oxidative stress
The effect of nicotine on the mechanical properties of mesenchymal stem cells
Ruiz JP, et al.
Cell health and cytoskeleton, 4, 29-29 (2012)
W Sihver et al.
Neuroscience, 94(3), 685-696 (1999-12-01)
The laminar binding distribution of three nicotinic receptor agonists, [3H](-)nicotine, [3H]cytisine, and [3H]epibatidine, and their relation to the [3H]vesamicol binding, which is known to represent the vesicular acetylcholine transport sites, was performed employing in vitro autoradiography on the medial temporal
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