产品名称
OATP1B3 Knockout HepaRG™ Cells, 1 vial
biological source
human female liver (hepatocarcinoma and hepatitis C tumor)
form
liquid
OMIM accession no.
storage temp.
−196°C
Quality Level
Gene Information
human ... OATP1B3(28234)
Analysis Note
Tested for Mycoplasma, sterility, post-freeze viability, short terminal repeat (STR) analysis for cell line identification, cytochrome oxidase I (COI) analysis for cell line species confirmation.
Application
See technical bulletin for detailed protocols
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Features and Benefits
Zinc finger nucleases (ZFN) mediated Knock-out of SLCO1B3 (MRP3) gene.
- The frame-shift mutation of SLCO1B3 gene was confirmed by fragment length analysis and DNA sequencing.
- Loss of functionality was confirmed by loss of transport of selective substrates in sandwich culture assay.
General description
HepaRG is a human hepatoma cell line. The cells possess a pseudodiploid karyotype and have been characterized as an oval ductular bipotent hepatic cell line as they have the ability to differentiate into both biliary and hepatocyte lineages in the presence of DMSO. HepaRG OATP1B3 knockout cells express the major xenobiotic sensors (PXR, CAR and AhR), drug transporters, phase I and II drug metabolizing enzymes as well as key hepatic transcription factors involved in stress response pathways.
Legal Information
These products are covered by the License Agreement as described in Exhibit 1, 2 and 3, in the technical bulletin.
HepaRG is a trademark of BioPredic International company
存储类别
12 - Non Combustible Liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
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商品
Oral drug delivery involves dissolution in the small intestine and absorption across the enterocyte barrier into the portal vein followed by subsequent delivery through the liver into the systemic circulation.
相关内容
成功筛选药物靶点和先导化合物发现需要经过检验、专用于特定工艺的高通量试剂和用品。查找适合您的CRO、制药或生物技术工艺的工具，进行小分子和生物药物筛选并以及稳定的药物安全性免疫原性检测。
High-throughput reagents for drug target screening and immunogenicity testing.
Instructions
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