usage
sufficient for 100 assays
detection method
fluorometric
relevant disease(s)
cancer
storage temp.
−20°C
General description
Cell cycle is a ubiquitous, complex sequence of events leading to growth and proliferation of cells. Cell cycle progression is tightly regulated due to its involvement in development, DNA damage and repair, etc. Anomalies in cell cycle progression can lead to tissue hyperplasia and diseases such as cancer. Cell cycle can be subdivided into interphase (G0/G1, S and G2) and mitotic (M) phase (prophase, metaphase, anaphase and telophase).
Application
- HMGB2 Upregulation Promotes the Progression of Hepatocellular Carcinoma Cells through the Activation of ZEB1/vimentin Axis.: This research employed cell cycle analysis to elucidate the role of HMGB2 in hepatocellular carcinoma. The findings highlighted how HMGB2 influences cell cycle dynamics and metastatic properties, emphasizing the kit′s application in cancer research (Lu et al., 2023).
- Exploring the Anti-Glioma Mechanism of the Active Components of Cortex Periplocae Based on Network Pharmacology and iTRAQ Proteomics In Vitro.: This study integrated cell cycle analysis with network pharmacology and iTRAQ proteomics to uncover the anti-glioma properties of Cortex Periplocae components. It demonstrated the comprehensive application of the kit in neuro-oncology research (Huan et al., 2023).
- ERH Gene Knockdown Inhibits the Proliferation and Migration of ARPE-19 Cells through MCM Complex and EMT Process.: Using a cell cycle analysis kit, this research identified the impact of ERH gene knockdown on cell proliferation and migration in ARPE-19 cells. The study underscored the kit′s role in gene function studies and cell biology (Li et al., 2023).
- Quantitative Proteomics Reveals Effects of Environmental Radiofrequency Electromagnetic Fields on Embryonic Neural Stem Cells.: This investigation used cell cycle analysis to study the effects of radiofrequency electromagnetic fields on embryonic neural stem cells. The findings provided valuable insights into environmental impacts on cell cycle and stem cell biology (An et al., 2023).
Suitable for studying cell cycle in adherent or suspension cells
Biochem/physiol Actions
The kit utilizes a nuclear dye, the binding of which to nucleic acids in the cell results in fluorescence signal, which is proportional to cellular DNA content. The percentages of cells in different phases of the cell cycle (G0/G1, S, and G2/M) can be quantified by flow cytometry.
Features and Benefits
The method is non-radioactive, rapid and accurate and can be used for high throughput cell cycle analysis with contemporary flow cytometer instruments.
存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
此项目有
相关内容
Instructions
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