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Merck
CN

MAK316

Sigma-Aldrich

亚铁血红素检测试剂盒

sufficient for 250 colorimetric tests

别名:

Heme Quantification Kit

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About This Item

UNSPSC代码:
12161503
NACRES:
NA.84

一般描述

血红素是卟啉家族的一员。在线粒体和细胞质中合成,是血红蛋白、细胞色素、过氧化氢酶和过氧化物酶等多种必需蛋白质的关键辅基。游离血红素在溶血后可从血红蛋白中释放,具有促炎作用,并促进铁衍生的活性氧。血红素测定被各种血液病研究者广泛实践。

特点和优势

与高通量处理系统兼容。

适用性

适用于血液、血浆、血清、尿液、携带酶的血红素等多种生物样品中血红素的定量测定及药物对血红素代谢影响的评价。

原理

血红素含量测定基于碱性水溶液法,其中血红素转化为均匀的有色形式,产生比色 (400 nm) 结果,与样品中的血红素浓度成正比。优化后的配方减少了干扰,表现出较高的灵敏度。1 mg/dL 血红素等于 15.3M、0.001% 或 10ppm。该试剂盒 96 孔格式的线性检测范围为 0.6-125M 血红素。

象形图

CorrosionEnvironment

警示用语:

Warning

危险声明

危险分类

Aquatic Acute 1 - Aquatic Chronic 2 - Eye Irrit. 2 - Met. Corr. 1

储存分类代码

8B - Non-combustible corrosive hazardous materials

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Role of heme and heme-proteins in trypanosomatid essential metabolic pathways.
Tripodi K E, et al.
Enzyme Research, 2011 (2011)
Yu-Yin Liu et al.
Reproduction (Cambridge, England), 158(3), 257-266 (2019-07-13)
Endometriosis (EMS) is a chronic inflammatory disease characterized by the presence of extrauterine endometrial tissues. It has been previously reported that the refluxed blood containing viable endometrial tissues and the defective elimination of peritoneal macrophages in the pelvic cavity may
Brell Jennifer et al.
Communications biology, 3(1), 621-621 (2020-10-29)
Iron is essential for living cells. Uptake of iron-loaded transferrin by the transferrin receptor 1 (CD71, TFR) is a major but not sufficient mechanism and an alternative iron-loaded ligand for CD71 has been assumed. Here, we demonstrate that CD71 utilizes
Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease.
Vinchi F, et al.
Blood, 127(4), 473-486 (2016)
Dietmar Hammerschmid et al.
Computational and structural biotechnology journal, 19, 1874-1888 (2021-05-18)
Globin-coupled sensors (GCS) usually consist of three domains: a sensor/globin, a linker, and a transmitter domain. The globin domain (GD), activated by ligand binding and/or redox change, induces an intramolecular signal transduction resulting in a response of the transmitter domain.

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