检测方法
fluorometric
相关疾病
cardiovascular diseases
储存温度
−20°C
一般描述
半胱氨酸(CYS)是人体的非必需含硫氨基酸，与胱氨酸有关。 半胱氨酸对于蛋白质合成、解毒和多种代谢功能很重要。 它存在于β-角蛋白中，β-角蛋白是指（趾）甲、皮肤和毛发中的主要蛋白。半胱氨酸对胶原生产，以及皮肤弹性和肌理也很重要。 作为抗氧化剂谷胱甘肽的组分，半胱氨酸在重要生化物质（如辅酶A、肝素和生物素）的代谢中起作用。 半胱氨酸总浓度升高可预测心血管疾病和代谢综合征风险。半胱氨酸缺乏是衰老的后果之一。
特点和优势
与高通量处理系统兼容。
适用性
适用于检测血清、血浆和其他生物体液中的半胱氨酸。
原理
半胱氨酸检测试剂盒测定各种生物学体液中半胱氨酸的生理浓度。检测原理是还原型半胱氨酸巯基裂解生成荧光产物（激发=365nm/发散=450nm），与样品中的总半胱氨酸含量成正比。该试剂盒具有特异性，其他巯基氨基酸不会造成干扰。该高通量适用性检测试剂盒简单灵敏，可在多种样本中检测到10 µM的半胱氨酸。
储存分类代码
10 - Combustible liquids
闪点(°F)
188.6 °F - closed cup
闪点(°C)
87 °C - closed cup
法规信息
常规特殊物品
Kazuki Hayashima et al.
The Journal of biological chemistry, 298(3), 101703-101703 (2022-02-13)
Ferroptosis is an iron-dependent mode of cell death caused by excessive oxidative damage to lipids. Lipid peroxidation is normally suppressed by glutathione peroxidase 4, which requires reduced glutathione. Cystine is a major resource for glutathione synthesis, especially in cancer cells.
Oxidative stress and ageing: is ageing a cysteine deficiency syndrome?
Droge W.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 360(1464), 2355-2372 (2005)
Virender Kumar Pal et al.
eLife, 10 (2021-11-19)
A fundamental challenge in human immunodeficiency virus (HIV) eradication is to understand how the virus establishes latency, maintains stable cellular reservoirs, and promotes rebound upon interruption of antiretroviral therapy (ART). Here, we discovered an unexpected role of the ubiquitous gasotransmitter
Xinbo Wang et al.
Cancer research, 81(20), 5217-5229 (2021-08-14)
Ferroptosis is a lipid peroxidation-dependent cell death caused by metabolic dysfunction. Ferroptosis-associated enzymes are promising therapeutic targets for cancer treatment. However, such therapeutic strategies show limited efficacy due to drug resistance and other largely unknown underlying mechanisms. Here we report
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