推荐产品
检测方法
fluorometric
相关疾病
neurological disorders
储存温度
−70°C
一般描述
β-Secretase has been implicated to be an excellent target for anti-amyloid therapy for the treatment of Alzheimer′s disease.
适用性
Suitable for the determination of ß-Secretase activity in biological and purified samples.
原理
The β-Secretase activity Assay Kit provides a convenient fluorescence method for detecting β-secretase activity in biological and purified samples. The assay utilizes a secretase-specific peptide conjugated to two reporter molecules EDANS and DABCYL. In the uncleaved form, the fluorescent emissions from EDANS are quenched by the physical proximity of the DABCYL moiety. Cleavage of the peptide by secretase physically separates EDANS and DABCYL allowing for the release of a fluorescent signal. The level of secretase enzymatic activity in samples is proportional to the level of fluorescence intensity.
危险声明
预防措施声明
危险分类
Aquatic Chronic 2
储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
SPIN90 Deficiency Ameliorates Amyloid β Accumulation by Regulating APP Trafficking in AD Model Mice.
Youngsoo Oh et al.
International journal of molecular sciences, 23(18) (2022-09-24)
Alzheimer's disease (AD), a common form of dementia, is caused in part by the aggregation and accumulation in the brain of amyloid β (Aβ), a product of the proteolytic cleavage of amyloid precursor protein (APP) in endosomes. Trafficking of APP
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