应用
pharmaceutical
检测方法
fluorometric
相关疾病
endocrinological disorders, diabetes
运输
wet ice
储存温度
−20°C
基因信息
human ... DPP4(1803)
mouse ... DPP4(13482)
rat ... DPP4(25253)
一般描述
二肽基肽酶 4（DPP4；CD26；腺苷脱氨酶络合蛋白-2）是一种具有丝氨酸外肽酶活性的膜糖蛋白，能从多肽的 N 端裂解 X 脯氨酸二肽。DPP4 抑制剂抑制 DPP4 对葡萄糖依赖性促胰岛素多肽和胰高血糖素样肽-1 的降解，已成为口服抗糖尿病药物。
特点和优势
兼容高通量操作系统。
适用性
适于筛选DPP4的抑制剂。
原理
DPP4 抑制剂筛选试剂盒是一种适用于高通量筛选潜在 DPP4 抑制剂的简单检测方法。通过切割底物以产生与存在的酶活性成比例的荧光产物（λex= 360 /λem= 460nm）来测量DPP4活性。测试将试验抑制剂的有效性与作为对照提供的 DPP4 抑制剂（西格列汀）进行比较。
仅试剂盒组分
产品编号
说明
- DPP4 Assay Buffer
- DPP4 Substrate
- DPP4 Enzyme
- DPP4 Inhibitor, Sitagliptin
储存分类代码
10 - Combustible liquids
闪点(°F)
188.6 °F - closed cup
闪点(°C)
87 °C - closed cup
法规信息
常规特殊物品
Paulina Kęska et al.
Nutrients, 14(4) (2022-02-27)
The ability of peptides from an aqueous and salt-soluble protein extract of dry-cured pork loins to inhibit the action of dipeptidyl peptidase IV was determined. This activity was assessed at different times of the production process, i.e., 28, 90, 180
Cleni Palma-Albino et al.
Antioxidants (Basel, Switzerland), 10(11) (2021-11-28)
Multifunctional peptides, capable of acting on different body systems through multiple mechanisms of action, offer many advantages over monofunctional peptides, including lower adverse side effects and costs. Erythrina edulis (pajuro) is a legume with a large number of high-quality proteins
Bingli Zhao et al.
Bioorganic chemistry, 99, 103772-103772 (2020-03-29)
Two key enzymes like α-glucosidase and dipeptidyl peptidase-4 (DPP4) play an important role in the development of Type 2 diabetes (T2D), and inhibiting them is a common treatment strategy for T2D. In this study, an ultrafiltration- centrifugation approach was developed
S Wupper et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 71(3) (2020-09-30)
Gamma-cyclodextrin (γCD) is a cyclic oligosaccharide consisting of eight α-(1,4)-linked glucopyranose subunits, which is often used in the food and pharmaceutical industries. However, little is known regarding the metabolic activity of "empty" γCD per se. Therefore, in the present study
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