application(s)
cosmetics
food and beverages
pharmaceutical
detection method
fluorometric
relevant disease(s)
cardiovascular diseases
storage temp.
−20°C
General description
胆固醇逆向转运 (RCT) 是通过转运至肝脏及其粪便排泄，降低外周脂质负荷的机制。RCT 的第一步是动脉粥样硬化斑块中巨噬细胞源性泡沫细胞的胆固醇流出。胆固醇外流对于维持动脉壁净胆固醇平衡和减少由富含脂质的巨噬细胞触发的促炎症反应至关重要。
Application
胆固醇外流测定试剂盒已用于胆固醇外流测定。
适用于细胞内胆固醇外流的测定。
Biochem/physiol Actions
胆固醇外排检测试剂盒是一种高通量筛选分析试剂盒，通过荧光标记的胆固醇检测细胞中的胆固醇外排(λEx = 482 nm/ λEm = 515 nm)。适用于血清、分离或重组脂蛋白样本。也可根据胆固醇外排作用筛选小分子，因此可作为有价值的药物发现工具。
Features and Benefits
兼容高通量操作系统。
仅试剂盒组分
产品编号
说明
- Labeling Reagent
- Equilibration Buffer
- Reagent A
- Reagent B
- Cell Lysis Buffer
- Positive Control
- Serum Treatment Reagent
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
存储类别
10 - Combustible liquids
flash_point_f
188.6 °F - closed cup
flash_point_c
87 °C - closed cup
Huifeng Pi et al.
Journal of cellular and molecular medicine, 23(8), 5259-5269 (2019-05-24)
The formation of fat-laden foam cells, which contributes to the fatty streaks in the plaques of atheromas, is an important process in atherosclerosis. Vascular smooth muscle cells (VSMCs) are a critical origin of foam cells. However, the mechanisms that underlie
Lipoprotein apheresis affects lipoprotein particle subclasses more efficiently compared to the PCSK9 inhibitor evolocumab, a pilot study.
Lappeg?rd K T, et al.
Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis, 57(1), 91-96 (2018)
Christian Abendstein Kjellmo et al.
Journal of clinical lipidology, 12(1), 193-202 (2017-11-18)
Bariatric surgery has been shown to reduce cardiovascular events and cause-specific mortality for coronary artery disease in obese patients. Lipoprotein biomarkers relating to low-density lipoprotein (LDL), high-density lipoprotein (HDL), their subfractions, and macrophage cholesterol efflux have all been hypothesized to
Bariatric surgery improves lipoprotein profile in morbidly obese patients by reducing LDL cholesterol, apoB, and SAA/PON1 ratio, increasing HDL cholesterol, but has no effect on cholesterol efflux capacity.
Kjellmo C A, et al.
Journal of Clinical Lipidology, 12(1), 193-202 (2018)
Knut Tore Lappegård et al.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis, 57(1), 91-96 (2018-02-06)
Lipoprotein apheresis and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are last therapeutic resorts in patients with familial hypercholesterolemia (FH). We explored changes in lipoprotein subclasses and high-density lipoprotein (HDL) function when changing treatment from lipoprotein apheresis to PCSK9 inhibition.
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