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用途
sufficient for 100 fluorometric tests
检测方法
fluorometric
相关疾病
endocrinological disorders, diabetes; gastrointestinal diseases; cancer
储存温度
−20°C
一般描述
脂肪酸对许多生物过程至关重要，包括能量代谢和结构细胞成分合成。据推测，通过脂肪酸转运蛋白促进脂肪酸摄入的过程，可在多个水平上受到调节。脂肪酸摄入失调可能导致肥胖症、2型糖尿病和肝脏脂肪变性等疾病。
适用性
该试剂盒适用于测量含脂肪酸转运蛋白的细胞的脂肪酸摄入
原理
该试剂盒为测量含脂肪酸转运蛋白的细胞的脂肪酸摄入提供了一种简单、灵敏的方法。该试剂盒使用独有的十二烷酸荧光脂肪酸底物，细胞摄入该底物将导致荧光强度增加（λex = 485/λem = 515 nm）。
储存分类代码
10 - Combustible liquids
Stephanie Kim et al.
Environmental health perspectives, 129(7), 77006-77006 (2021-07-30)
Chemicals in disparate structural classes activate specific subsets of the transcriptional programs of peroxisome proliferator-activated receptor-γ (PPARγ) to generate adipocytes with distinct phenotypes. Our objectives were to a) establish a novel classification method to predict PPARγ ligands and modifying chemicals;
Mona S Nilsen et al.
Diabetes, 69(9), 1903-1916 (2020-06-27)
Circulating branched-chain amino acids (BCAAs) associate with insulin resistance and type 2 diabetes. 3-Hydroxyisobutyrate (3-HIB) is a catabolic intermediate of the BCAA valine. In this study, we show that in a cohort of 4,942 men and women, circulating 3-HIB is
Rong Huang et al.
JCI insight, 4(18) (2019-09-20)
Age is a well-established risk factor for impaired bone fracture healing. Here, we identify a role for apolipoprotein E (ApoE) in age-associated impairment of bone fracture healing and osteoblast differentiation, and we investigate the mechanism by which ApoE alters these
Stephanie Kim et al.
Archives of toxicology, 94(9), 3087-3103 (2020-07-20)
Triphenyl phosphate (TPhP) is an environmental PPARγ ligand, and growing evidence suggests that it is a metabolic disruptor. We have shown previously that the structurally similar ligand, tributyltin, does not induce brite adipocyte gene expression. Here, using in vivo and
Xingzhe Ma et al.
Cell metabolism, 33(5), 1001-1012 (2021-03-11)
Understanding the mechanisms underlying how T cells become dysfunctional in a tumor microenvironment (TME) will greatly benefit cancer immunotherapy. We found that increased CD36 expression in tumor-infiltrating CD8+ T cells, which was induced by TME cholesterol, was associated with tumor progression and
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