推荐产品
用途
sufficient for 100 fluorometric tests
应用
pharmaceutical
检测方法
fluorometric
相关疾病
cardiovascular diseases
储存温度
2-8°C
基因信息
human ... MTTP(4547)
一般描述
微粒体甘油三酯转移蛋白（MTP），一种存在于肝脏中的膜结合蛋白，可在极低密度脂蛋白（VLDL）的组装和分泌中起到重要作用。MTP对于肠内乳糜微粒的组装和分泌也是必需的。该蛋白有助于甘油三酯（TG）、胆固醇酯（CE）和磷脂酰胆碱（PC）在磷脂表面之间的转移。 MTP基因中的突变可导致无β脂蛋白血症。
应用
MTP活性检测试剂盒已被用于测量微粒体甘油三酯转移蛋白（MTP）的活性。
特点和优势
兼容高通量操作系统。
适用性
适用于测量细胞裂解液或组织匀浆液中微粒体[甘油三酯]转移蛋白（MTP）的活性，或用于筛选MTP活性抑制剂。
原理
MTP活性检测试剂盒是一种灵敏的均质荧光检测方法，可用于细胞裂解物或组织匀浆中中MTP活性的连续测量。该试剂盒包括能够检测 MTP 介导的中性脂质转移的专有底物。 这种转移活性导致荧光强度增加（λEx=465 nm/λEm=535 nm）。
储存分类代码
10 - Combustible liquids
法规信息
常规特殊物品
J Massart et al.
British journal of pharmacology, 165(5), 1361-1374 (2011-07-12)
Pentoxifylline is in clinical trials for non-alcoholic fatty liver disease and diabetic nephropathy. Metabolic and hepatic effects of pentoxifylline were assessed in a murine model of obesity and type 2 diabetes. Pentoxifylline (100 mg·kg(-1) ·day(-1)) was administered for 4 days
Thi Thu Trang Tran et al.
The Journal of biological chemistry, 291(31), 16328-16338 (2016-06-04)
The worldwide prevalence of metabolic diseases is increasing, and there are global recommendations to limit consumption of certain nutrients, especially saturated lipids. Insulin resistance, a common trait occurring in obesity and type 2 diabetes, is associated with intestinal lipoprotein overproduction.
Microsomal triglyceride transfer protein specificity of lipid binding and transport.
Jamil H, et al.
The Journal of Biological Chemistry, 270(12), 6549-6554 (1995)
The microsomal triglyceride transfer protein catalyzes the post-translational assembly of apolipoprotein B-100 very low density lipoprotein in McA-RH7777 cells.
Rustaeus S, et al.
The Journal of Biological Chemistry, 273(9), 5196-5203 (1998)
Jonathan Goldwasser et al.
Journal of hepatology, 55(5), 963-971 (2011-03-01)
Hepatitis C virus (HCV) infection affects 3% of the world population and is the leading cause of chronic liver disease worldwide. Current standard of care is effective in only 50% of the patients, poorly tolerated, and associated with significant side
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门