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安全信息

MAK107

Sigma-Aldrich

LCAT 活性检测试剂盒

Supplied by Roar Biomedical, Inc.

别名:

Lecithin:胆固醇酰基转移酶活性检测试剂盒

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About This Item

EC 号:
200-659-6
UNSPSC代码:
12161503
NACRES:
NA.84

用途

sufficient for 100 fluorometric tests

应用

pharmaceutical

检测方法

fluorometric

相关疾病

cardiovascular diseases

储存温度

−20°C

基因信息

human ... LCAT(3931)

一般描述

血浆蛋白卵磷脂胆固醇酰基转移酶（LCAT）可催化酰基从磷脂酰胆碱的sn2位转移到胆固醇的3-羟基，从而生成胆固醇酯。这种酶活性发生在高密度脂蛋白（HDL）的表面。由LCAT生成的胆固醇酯可以填充到HDL的核心。

应用

LCAT活性测定试剂盒用于测定血浆样品中的卵磷脂胆固醇酰基转移酶活性。
该方法的应用包括高通量筛选、作用机制研究和构效关系（SAR）研究。

特点和优势

兼容高通量操作系统。

适用性

适用于测定血浆或血清中LCAT的磷脂酶活性。

原理

LCAT活性检测试剂盒 是用于测定LCAT（卵磷脂胆固醇酰基转移酶）磷脂酶活性的荧光检测法(λEx=390 nm/λEm=470 nm)。该测定可以通过用碘乙酸盐或另一种光谱上良性（非Ellman′s试剂）LCAT抑制剂抑制LCAT进行验证。

分析说明

了解更多关于Roar检测试剂盒在脂蛋白代谢中的研究。

仅试剂盒组分

产品编号
说明
  • Substrate Reagent .1 mL
  • READ Reagent 30 mL
  • LCAT Assay Buffer 20 mL

警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

储存分类代码

3 - Flammable liquids

闪点(°F)

49.5 °F

闪点(°C)

9.7 °C

法规信息

危险化学品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
RBH5080V
RBH5080V
RBH5078V
RBH5076V
RBH5074V

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Are products MAK107 and MAK108 compatible with mouse serum?

    Yes, but please be aware of possible sample hemolysis. Depending on the method of mouse sample collection, hemolysis may be common, which can interfere with fluorescence emission via color quenching.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Agnieszka Kuchta et al.
International journal of molecular sciences, 20(5) (2019-03-13)
In chronic kidney disease (CKD), the level of high-density lipoprotein (HDL) decreases markedly, but there is no strong inverse relationship between HDL-cholesterol (HDL-C) and cardiovascular diseases. This indicates that not only the HDL-C level, but also the other quantitative changes
Carey J Ng et al.
Arteriosclerosis, thrombosis, and vascular biology, 27(6), 1368-1374 (2007-04-21)
We have previously reported that human paraoxonase 3 (PON3) is an HDL-associated protein capable of preventing LDL oxidation in vitro. The objective of the present study was to determine whether elevated levels of human PON3 in mice could protect against
Mitigating efficacy of piperine in the physiological derangements of high fat diet induced obesity in Sprague Dawley rats.
BrahmaNaidu P, et al.
Chemico-Biological Interactions, 221, 42-51 (2014)
Daniel J Conklin et al.
Toxicology and applied pharmacology, 243(1), 1-12 (2009-12-26)
Aldehydes such as acrolein are ubiquitous pollutants present in automobile exhaust, cigarette, wood, and coal smoke. Such aldehydes are also constituents of several food substances and are present in drinking water, irrigation canals, and effluents from manufacturing plants. Oral intake
E Nobécourt et al.
Diabetologia, 48(3), 529-538 (2005-02-25)
Elevated oxidative stress, hyperglycaemia, and dyslipidaemia involving low levels of HDL particles are key proatherogenic factors in type 2 diabetes mellitus. We examined the relationship of oxidative stress, and the degree of glycaemia and triglyceridaemia, to antioxidative function of HDL
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