用途
sufficient for 100 colorimetric or fluorometric tests
检测方法
colorimetric
fluorometric
相关疾病
rheumatological diseases; gastrointestinal diseases; cardiovascular diseases
储存温度
−20°C
基因信息
human ... XDH(7498)
mouse ... XDH(22436)
rat ... XDH(497811)
一般描述
黄嘌呤氧化酶催化次黄嘌呤依次氧化为黄嘌呤，黄嘌呤依次氧化为尿酸和过氧化氢。在人类和其他灵长类动物中，XO控制嘌呤分解代谢的最后一步，通常在肝脏和肠粘膜中发现。在啮齿动物中，XO在大多数组织中广泛表达。虽然血液中XO活性通常很低，但肝损伤会导致XO释放到血液中。XO可能参与痛风和心血管疾病的发病机制，XO活性或表达可能在这些情况下上调。
应用
黄嘌呤氧化酶活性检测试剂盒已用于测量血清样品中的黄嘌呤氧化酶。
适用性
适用于各种样品（包括组织、细胞和血清）中黄嘌呤氧化酶的测量
原理
黄嘌呤氧化酶活性检测试剂盒为测量各种生物样品中的XO活性提供了简单而直接的程序。XO活性由偶联酶测定法测定，结果比色（570 & # 160；nm）/荧光计（& # 955；ex = 535/& # 955；em = 587 & # 160nm）产品，与生成的过氧化氢成比例。XO的一个单位被定义为催化黄嘌呤在25 °C下每分钟氧化产生1.0 & # 160；& # 956；摩尔尿酸和过氧化氢的酶量。
储存分类代码
10 - Combustible liquids
Neelam Malik et al.
BMC chemistry, 13(1), 53-53 (2019-08-07)
Hesperitin, a naturally occurring flavonoid was hybridized with phenolic acids to evaluate its potential to inhibit the activity of xanthine oxidase (XO), a key enzyme which catalyses xanthine to uric acid which is found to be associated with gout and
Neelam Malik et al.
Medicinal chemistry (Shariqah (United Arab Emirates)), 16(5), 643-653 (2019-10-05)
Xanthine oxidase (XO; EC 1.17.3.2) has been considered as a potent drug target for the cure and management of pathological conditions prevailing due to high levels of uric acid in the bloodstream. The role of xanthine oxidase has been well
Probiotic therapy alleviates hyperuricemia in C57BL/6 mouse model.
Cao T, et al.
Biomedical Research, 28(5) (2017)
Shivangi Rastogi et al.
PLoS pathogens, 17(7), e1009712-e1009712 (2021-07-30)
Mycobacterium tuberculosis (Mtb) has evolved to evade host innate immunity by interfering with macrophage functions. Interleukin-1β (IL-1β) is secreted by macrophages after the activation of the inflammasome complex and is crucial for host defense against Mtb infections. We have previously
Neelam Malik et al.
BMC chemistry, 13(1), 71-71 (2019-08-07)
Xanthine oxidase is an important enzyme of purine catabolism pathway and has been associated directly in pathogenesis of gout and indirectly in many pathological conditions like cancer, diabetes and metabolic syndrome. In this research rutin, a bioactive flavonoid was explored
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