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用途
sufficient for 100 colorimetric tests
检测方法
colorimetric
相关疾病
cancer
储存温度
−20°C
一般描述
富马酸是琥珀酸脱氢酶氧化琥珀酸形成的三羧酸(TCA)循环中间体。在哺乳动物肝脏中，富马酸盐也是尿素循环的产物，其在细胞质中的释放导致其转化为苹果酸盐，随后转化成草酰乙酸盐，同时在细胞质中生成 NADH。富马酸盐水合酶的缺乏与富马酸盐的细胞浓度增加和肾细胞癌的发病率升高有关。这很可能是由富马酸盐介导的 HIF1 上调引起的。Fumarate 检测试剂盒是灵敏地检测各种样品中富马酸的便利的工具。
应用
Fumarate 检测试剂盒已用于测定样品中富马酸的浓度。
适用性
适用于检测各种样品中的富马酸盐，包括组织、细胞和血清
原理
通过酶测定法测定富马酸盐，其产生与存在的富马酸盐成比例的比色（450nm）产物。
警示用语：
Danger
危险声明
危险分类
Eye Dam. 1 - Skin Corr. 1B
储存分类代码
8A - Combustible corrosive hazardous materials
法规信息
含少量动物源组分生物产品
常规特殊物品
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Combined effects of FH (E404D) and ACOX2 (R409H) cause metabolic defects in primary cardiac malignant tumor.
Zhou X, et al.
Cell Death & Disease, 5(1), 18-18 (2018)
Yijing Zhuang et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 39(4), 1307-1316 (2016-09-09)
Motility is a feature of many pathogens that contributes to the migration and dispersion of the infectious agent. Whether gentamycin has a post-antibiotic effect (PAE) on the swarming and swimming motility of Escherichia coli (E. coli) remains unknown. In this
Melatonin alleviates adipose inflammation through elevating α-ketoglutarate and diverting adipose-derived exosomes to macrophages in mice.
Liu Z, et al.
Journal of Pineal Research, 64(1), e12455-e12455 (2018)
Xiangyu Zhou et al.
Cell death discovery, 4, 18-18 (2018-08-01)
Primary malignant cardiac tumors (PMCTs) are extremely rare. The apparent immunity of the heart to invasive cancer has attracted considerable interest given the continuously rising incidence of cancer in other organs. This study aims to determine the conditions that could
Meixi Peng et al.
Cell death & disease, 10(3), 228-228 (2019-03-10)
Citrate, a substance being related to de novo fatty acid synthesis and tricarboxylic acid (TCA) cycle, has a pivotal role in cell survival. However, the molecular mechanisms that regulate intracellular citrate in triple-negative breast cancer (TNBC), especially under hypoxic condition
商品
本文介绍了增殖活性细胞为何需要碳源和氮源合成大分子。尽管大部分肿瘤细胞利用有氧糖酵解途径并分流线粒体氧化磷酸化代谢物，但许多肿瘤细胞表现出线粒体活性增加。
Sigma article discusses tumor cell metabolic pathways, focusing on aerobic glycolysis and mitochondrial activity.
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