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用途
sufficient for 100 colorimetric or fluorometric tests
应用
cosmetics
food and beverages
检测方法
colorimetric
fluorometric
相关疾病
cancer
储存温度
−20°C
一般描述
柠檬酸是三羧酸（TCA）循环的关键中间体，通过向乙酰辅酶A的乙酰基中加入草酰乙酸而得。柠檬酸通过柠檬酸-苹果酸梭子从线粒体中转运出来，然后转化回乙酰辅酶A进行脂肪酸合成。柠檬酸是脂肪酸合成和糖酵解的别构调节剂，分别通过作用于乙酰辅酶A羧化酶和磷酸果糖激酶来实现。由于性别、年龄和各种其他因素（包括疾病状态），柠檬酸的代谢和分布差异可能很大。前列腺癌细胞中的细胞柠檬酸水平降低，柠檬酸水平可能是前列腺癌生长速率的标志物。柠檬酸检测试剂盒提供了一种可简单、灵敏、快速地对各种样品中的柠檬酸进行定量的方法。
应用
柠檬酸检测试剂盒用于检测样品中柠檬酸的浓度。
适用性
适用于对包括组织和细胞在内的多种样品中的柠檬酸盐进行测定
原理
柠檬酸的浓度通过酶偶联法检测，产生与存在的柠檬酸成比例的比色（570 nm）/荧光（λex = 535/λem = 587 nm）产物。柠檬酸检测试剂盒的灵敏度在各种样品中通常为0.1至10 nM（2 μmM-10 mM）柠檬酸。
相关产品
危险声明
预防措施声明
危险分类
Aquatic Chronic 3
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
188.6 °F - closed cup
闪点(°C)
87 °C - closed cup
法规信息
监管及禁止进口产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
High-intensity sprint training inhibits mitochondrial respiration through aconitase inactivation.
Larsen F J, et al.
Faseb Journal, 30(1), 417-427 (2015)
Ricardo Villa-Bellosta et al.
Scientific reports, 9(1), 11374-11374 (2019-08-08)
Vascular calcification is highly prevalent in patients with chronic hemodialysis. Increased acetatemia during hemodialysis sessions using acetate-acidified bicarbonate has also been associated with several abnormalities, By contrast, these abnormalities were not induced by citrate-acidified bicarbonate dialysis. Moreover, citrate is biocompatible
Nimrit Goraya et al.
Kidney international, 95(5), 1190-1196 (2019-03-09)
Acid (H+) retention appears to contribute to progressive decline in glomerular filtration rate (GFR) in patients with chronic kidney disease (CKD), including some patients without metabolic acidosis. Identification of patients with H+ retention but without metabolic acidosis could facilitate targeted
Yan Huang et al.
Regenerative biomaterials, 7(2), 221-232 (2020-04-17)
The purpose of this article was to explore the effects of gold nanoparticles (GNPs) and silver nanoparticles (SNPs) with different cytotoxicities on human dermal fibroblasts (HDFs) at the metabolic level. First, ∼20 nm of GNPs and SNPs were prepared, and their
Jade D Bailey et al.
Cell reports, 28(1), 218-230 (2019-07-04)
Classical activation of macrophages (M(LPS+IFNγ)) elicits the expression of inducible nitric oxide synthase (iNOS), generating large amounts of NO and inhibiting mitochondrial respiration. Upregulation of glycolysis and a disrupted tricarboxylic acid (TCA) cycle underpin this switch to a pro-inflammatory phenotype.
商品
Fatty acid synthesis supports cancer cell proliferation, essential for membrane generation, protein modification, and bioenergetics.
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