usage
sufficient for 100 colorimetric tests
detection method
colorimetric
relevant disease(s)
endocrinological disorders, diabetes; cancer; gastrointestinal diseases
storage temp.
−20°C
General description
β-羟基丁酸盐，也称为3-羟基丁酸盐，是一种酮体，主要由脂肪酸氧化在肝脏中合成。当血糖水平下降时，酮体形成，即生酮作用，会升高。中度升高的血酮体通常发生在禁食和长期运动期间。在酒精或糖尿病酮症酸中毒期间，血液中的β-羟基丁酸盐会上升到异常高的水平。β-羟基丁酸盐可用作肝脏能量代谢的标记物。β-羟基丁酸盐的形成随着乙酰辅酶A的过量而增加，并作为大脑的能量来源。
Application
β-羟基丁酸盐检测试剂盒已用于
- 量化血浆/血清中的β-羟基丁酸盐水平
- 通过测定血浆酮体水平，研究延长生酮饮食后心肌18F-FDG摄取的变化
- 研究β-羟基丁酸盐在治疗脊髓损伤小鼠的损伤和神经病理性疼痛方面的作用
适合测量生物样本（包括血清和尿液）中的β-羟基丁酸盐水平
Biochem/physiol Actions
在这个检测中，β-羟基丁酸盐浓度由偶联酶反应确定，这产生比色（450 nm）产物，与存在的β-羟基丁酸盐成比例。
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B
存储类别
8A - Combustible corrosive hazardous materials
法规信息
监管及禁止进口产品
此项目有
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Knudsen J G, et al.
Physiological Reports, 4(9), e12788-e12788 (2016)
Yongsheng Yu et al.
European journal of pharmacology, 829, 121-128 (2018-04-22)
The present study was designed to examine the protection of D-β-hydroxybutyrate (BHB) against ischemia/reperfusion (I/R) injury in heart and investigate its underlying mechanism. Male adult mice were exposed to 30 min of ischemia and 24 h of reperfusion. Osmotic pumps were implanted
Jenni Määttä et al.
Scientific reports, 8(1), 13583-13583 (2018-09-13)
Hypoxia of residence at high altitude (>2500 m) decreases birth weight. Lower birth weight associates with infant mortality and morbidity and increased susceptibility to later-in-life cardiovascular and metabolic diseases. We sought to determine the effects of hypoxia on maternal glucose and
Tumor metabolism, the ketogenic diet and β-hydroxybutyrate: novel approaches to adjuvant brain tumor therapy
Woolf E C, et al.
Frontiers in Molecular Neuroscience, 9, 122-122 (2016)
Chao Huang et al.
Glia, 66(2), 256-278 (2017-10-24)
Direct induction of macrophage ramification has been shown to promote an alternative (M2) polarization, suggesting that the ramified morphology may determine the function of immune cells. The ketone body metabolite β-hydroxybutyrate (BHB) elevated in conditions including fasting and low-carbohydrate ketogenic
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