用途
sufficient for 100 colorimetric or fluorometric tests
检测方法
colorimetric
fluorometric
储存温度
−20°C
一般描述
现在我们可提供全新的ADP检测试剂盒MAK518！腺苷二磷酸(ADP)是一种核苷二磷酸，在能量转移反应中起关键作用。ADP是在ATP酶的作用下，由腺苷三磷酸 (ATP)生产。ADP也在血小板的功能中起关键作用。ADP储存在血小板致密颗粒（platelet-dense granule）中，通过血小板的活化释放，在这一过程中ADP作用于嘌呤受体，从而介导胞内信号传导和血小板聚集。ADP是血栓形成和止血的关键激动剂。
特点和优势
兼容高通量操作系统。
适用性
适用于测定多种生物样本中的 ADP，包括细胞和组织裂解物
原理
在该试验中，通过偶联酶反应测定 ADP（二磷酸腺苷）浓度，得到比色 (570 nm)/荧光 (λ ex = 535/λ em = 587 nm) 乘积，与存在的 ADP 成比例。
警示用语：
Danger
危险声明
危险分类
Resp. Sens. 1 - Skin Sens. 1
储存分类代码
10 - Combustible liquids
闪点(°F)
188.6 °F - closed cup
闪点(°C)
87 °C - closed cup
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The American Journal of Psychiatry, 158(12), 2048-2055 (2001)
ADP is not an agonist at P2X1 receptors: evidence for separate receptors stimulated by ATP and ADP on human platelets.
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British Journal of Pharmacology, 131(1), 108-114 (2000)
Jianmin Zhang et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 39(9), 1836-1848 (2018-04-17)
Neuronal preconditioning in vitro or in vivo with a stressful but non-lethal stimulus leads to new protein expression that mediates a profound neuroprotection against glutamate excitotoxicity and experimental stroke. The proteins that mediate neuroprotection are relatively unknown and under discovery.
Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs.
Foster C J, et al.
The Journal of Clinical Investigation, 107(12), 1591-1598 (2001)
Ana Luisa Palacios-Acedo et al.
Frontiers in oncology, 11, 704945-704945 (2021-10-01)
Platelet function can be modified by cancer cells to support tumor growth, causing alterations in the delicate hemostatic equilibrium. Cancer-cell and platelet interactions are one of the main pillars of Trousseau's syndrome: a paraneoplastic syndrome with recurring and migrating episodes
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