用途
sufficient for 100 colorimetric tests
检测方法
colorimetric
相关疾病
endocrinological disorders, diabetes; gastrointestinal diseases; neurological disorders
储存温度
−20°C
一般描述
支链氨基酸 (BCAA)、亮氨酸、异亮氨酸和缬氨酸是蛋白质中最常见的必需氨基酸。BCAA 可能在能量生产和营养信号中发挥作用。膳食补充 BCAA 可能有助于治疗各种疾病，如肌萎缩侧索硬化 (ALS)、隐匿性和慢性肝性脑病 ，并预防癌症患者的肌肉萎缩。BCAA 可增加蛋白质合成速率，使细胞对胰岛素和胰岛素样生长因子敏感。
应用
在一项评估 CREB 调节的转录辅激活因子 2 角色 （CRTC2）在小鼠肝脏脂质稳态和肥胖中的作用的研究中，支链氨基酸试剂盒已被用于测定肝脏支链氨基酸的浓度。
适用性
适用于测定多种生物样品中的支链氨基酸 (BCAA)。
原理
在该试验中，使用偶联酶反应测定 BCAA 浓度，得到与存在的 BCAA 成比例的比色 (450 nm) 产物。BCAA 检测试剂盒为测定各种生物样本中的 BCAA 提供了一种简单方便的方法。
警示用语：
Danger
危险声明
危险分类
Eye Dam. 1 - Skin Corr. 1B
储存分类代码
8A - Combustible corrosive hazardous materials
法规信息
常规特殊物品
Juliane Zemdegs et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(30), 5935-5948 (2019-06-05)
Epidemiological studies indicate that insulin resistance (IR), a hallmark of type 2 diabetes, is associated with an increased risk of major depression. Here, we demonstrated that male mice fed a high-fat diet (HFD) exhibited peripheral metabolic impairments reminiscent of IR
Wouter De Haes et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(24), E2501-E2509 (2014-06-04)
The antiglycemic drug metformin, widely prescribed as first-line treatment of type II diabetes mellitus, has lifespan-extending properties. Precisely how this is achieved remains unclear. Via a quantitative proteomics approach using the model organism Caenorhabditis elegans, we gained molecular understanding of
Natasha Fillmore et al.
American journal of physiology. Endocrinology and metabolism, 315(5), E1046-E1052 (2018-08-15)
Recent studies have proposed that elevated branched-chain amino acids (BCAAs) may induce insulin resistance (IR) in muscle secondary to increased BCAA oxidation inhibiting glucose oxidation (GO) and fatty acid oxidation (FAO). However, BCAA oxidation rates have not been assessed in
Multifaceted role of insulin-like growth factors and mammalian target of rapamycin in skeletal muscle.
Frost R A and Charles H L
Endocrinol. Metab. Clin., 41(2), 297-322 (2012)
Itziar Lamiquiz-Moneo et al.
Cells, 9(3) (2020-03-18)
The global prevalence of type 2 diabetes (T2D) is increasing rapidly, especially in low- and middle-income countries and has a high number of associated comorbidities. Plasmatic concentrations of branched chain amino acids (BCAA) and retinol-binding protein 4 (RBP4) have been
商品
Assay protocol for the colorimetric detection of Branched Chain Amino Acids (BCAA) in biological samples using the alanine assay kit.
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