所有图片(1)
About This Item
线性分子式:
H2NC(=NH)NHSCH2CH3 · 1/2 H2SO4
CAS号:
分子量:
168.23
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77
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方案
≥98%
表单
solid
运输
wet ice
储存温度
2-8°C
SMILES字符串
OS(O)(=O)=O.NC(=N)NCCS.NC(=N)NCCS
InChI
1S/2C3H9N3S.H2O4S/c2*4-3(5)6-1-2-7;1-5(2,3)4/h2*7H,1-2H2,(H4,4,5,6);(H2,1,2,3,4)
InChI key
XJKZAAUVINNNNC-UHFFFAOYSA-N
应用
Selective iNOS inhibitor and scavenger of peroxynitrite.
生化/生理作用
Demonstrates potent antiinflammatory effects in an animal model of airway infection that mimics human cystic fibrosis.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
K Soejima et al.
Burns : journal of the International Society for Burn Injuries, 27(8), 809-815 (2001-11-24)
This study tested the hypothesis that nitric oxide (NO) synthesized from inducible NO synthase (iNOS) is responsible for the cardiac dysfunction observed after burn and smoke inhalation injury. Twelve sheep received 40% third-degree burn and smoke inhalation under halothane anesthesia.
David W Paquette et al.
Journal of periodontology, 77(3), 385-391 (2006-03-04)
Nitric oxide is a free radical produced in host tissues by constitutive and inducible forms of the enzyme nitric oxide synthase. Nitric oxide plays physiological roles, but it is also involved in the pathophysiology of several inflammatory conditions, including arthritis
Ahmet Guven et al.
Renal failure, 30(7), 747-754 (2008-08-16)
Nitric oxide (NO) and peroxynitrite (OONO-) are implicated in the pathophysiology of renal ischemia/reperfusion (I/R). The aim of this study was to investigate and compare the efficiency of S-methylisothiourea (SMT), an iNOS inhibitor, and mercaptoethylguanidine (MEG), a scavenger of peroxynitrite
A Szabó et al.
Critical care medicine, 27(7), 1343-1350 (1999-08-14)
In rodent models, enhanced formation of nitric oxide and formation of peroxynitrite have been implicated in the pathogenesis of various forms of shock. Here we examined the effect of mercaptoethylguanidine (MEG), an inducible nitric oxide synthase inhibitor and peroxynitrite scavenger
M Whiteman et al.
British journal of pharmacology, 126(7), 1646-1652 (1999-05-14)
1. Peroxynitrite is a cytotoxic species that can be formed, among other mechanisms, by the rapid reaction of superoxide with nitric oxide. Peroxynitrite formation has been implicated in a wide range of neurodegenerative and chronic inflammatory diseases, as has the
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