推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
lyophilized powder
种属反应性
mouse, rat
技术
immunoblotting: 1:200 using rat brain membranes
immunohistochemistry: suitable
UniProt登记号
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CHRM1(1128)
rat ... Chrm1(25229)
一般描述
毒蕈碱乙酰胆碱受体1（M1）属于A类G蛋白偶联受体（GPCR）家族的一员，由CHRM1基因所编码。毒蕈碱受体具有位于副交感神经突触下膜上的七个跨膜结构域。CHRM1基因位于人染色体11q12.3上。
毒蕈碱胆碱能受体1（M1）在大鼠的前脑中可见。
免疫原
人 M 1 毒蕈碱乙酰胆碱受体 (mAChR) 的 i3 胞内环的一部分的 GST 融合蛋白，对应于 227-353 氨基酸残基。1、 2
生化/生理作用
毒蕈碱乙酰胆碱受体1（M1）可调节正常的前列腺生长和降低水平的腺体分泌。毒蕈碱受体可在肿瘤进展中起主要作用。毒蕈碱乙酰胆碱受体（mAChR）可调节腺苷酸环化酶和钾通道活性。它还可刺激各种丝裂原活化蛋白激酶。M1可能有助于发现阿尔茨海默′病的治疗方法。
研究表明，大鼠中毒蕈碱胆碱能受体1（M1）的激活会导致肝脏内毒素耐受性出现变化。
外形
从含有1%牛血清白蛋白和0.05%叠氮化钠的磷酸盐缓冲盐水（pH 7.4）中冻干。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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