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重组
expressed in E. coli
质量水平
检测方案
≥95% (SDS-PAGE)
形式
buffered aqueous glycerol solution
分子量
calculated mol wt 20.3 kDa
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... MMP12(4321)
一般描述
Matrix metalloproteinase-12 (MMP-12) is also called as macrophage metalloelastase and is secreted by inflammatory macrophages. It is synthesized as a zymogen and then activated by cleaving the propeptide domain. The MMP-12 gene is localized on chromosome 11.
生化/生理作用
MMP-12 degrades general matrix components and may have a role in processes such as host defense, cell proliferation, and protein turnover as well as tissue remodeling.
Matrix metalloproteinase-12 (MMP-12) breaks down proteoglycans, collagen type IV and laminin. Its main substrate is elastin.
单位定义
One unit equals 100 pmol/min at 37 °C using the colorimetric thiopeptolide Ac-Pro-Leu-Gly-S-Leu-Leu-Gly-OEt as substrate.
外形
Solution in 50 mM Tris, 5 mM calcium chloride, 500 mM sodium chloride, 20 μM zinc chloride, 0.5% Brij® L23, and 30% glycerol, pH 9.5.
法律信息
Brij is a registered trademark of Croda International PLC
危险声明
预防措施声明
危险分类
Aquatic Chronic 3
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
Matthew Traylor et al.
PLoS genetics, 10(7), e1004469-e1004469 (2014-08-01)
Genome-wide association studies (GWAS) have begun to identify the common genetic component to ischaemic stroke (IS). However, IS has considerable phenotypic heterogeneity. Where clinical covariates explain a large fraction of disease risk, covariate informed designs can increase power to detect
Yi Song et al.
BMC cardiovascular disorders, 13, 34-34 (2013-05-07)
Aortic dissection(AD) is an acute process of large blood vessels characterized by dangerous pathogenic conditions and high disability and high mortality. The pathogenesis of AD remains debated. Matrix metalloproteinase-12 (MMP-12) participates in many pathological processes such as abdominal aortic aneurysm
A Belaaouaj et al.
The Journal of biological chemistry, 270(24), 14568-14575 (1995-06-16)
Human macrophage metalloelastase (HME) is a recent addition to the matrix metalloproteinase (MMP) family that was initially found to be expressed in alveolar macrophages of cigarette smokers. To understand more about HME expression, analysis of the structure and location of
S D Shapiro
Current opinion in cell biology, 10(5), 602-608 (1998-11-18)
Targeted mutagenesis has allowed investigators to perform controlled experiments in mammals and determine the contribution of individual proteins to physiologic and pathologic processes. Recent lessons learned from matrix metalloproteinase gene targeted mice and other in vivo observations have given new
S D Shapiro et al.
The Journal of biological chemistry, 268(32), 23824-23829 (1993-11-15)
Human alveolar macrophages have the capacity to degrade elastin. As an approach to define proteinases responsible for this activity, we recently cloned a murine macrophage elastase cDNA and demonstrated that it is a member of the matrix metalloproteinase gene family
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