生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
lyophilized powder
种属反应性
rat
技术
immunoblotting: 1:2,000 (using ECL on rat brain lysate.)
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CHRM3(1131)
mouse ... Chrm3(12671)
rat ... Chrm3(24260)
一般描述
Muscarinic acetylcholine receptor M3 possesses a vestibule which is a part of a hydrophilic channel having a orthosteric binding site.
特异性
Muscarinic acetylcholine receptor m3.
免疫原
Synthetic peptide from the third extracellular loop of rat m3 (Accession P08483).
生化/生理作用
Muscarinic acetylcholine receptor M3 functions as a protectant in myocardial ischemia. It also has roles in smooth muscle contraction and glandular secretion. The receptor has a specific affinity for the Gq/11 family of G proteins.
目标描述
Muscarinic Acetylcholine Receptor M3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue.
外形
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.05% sodium azide as a preservative.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Patricia C Borck et al.
Clinical and experimental pharmacology & physiology, 47(2), 286-293 (2019-10-21)
Here, we investigate the effects of exercise training on glucose- and cholinergic-induced insulin secretion in pancreatic islets from obese and lean rats. Male Wistar rats were treated with monosodium glutamate (MSG) for the first 5 days of life, while control (CON)
Andrew C Kruse et al.
Nature, 482(7386), 552-556 (2012-02-24)
Acetylcholine, the first neurotransmitter to be identified, exerts many of its physiological actions via activation of a family of G-protein-coupled receptors (GPCRs) known as muscarinic acetylcholine receptors (mAChRs). Although the five mAChR subtypes (M1-M5) share a high degree of sequence
Zhenyu Pan et al.
PloS one, 7(3), e32571-e32571 (2012-03-08)
The M(3) subtype of muscarinic acetylcholine receptors (M(3)-mAChR) plays a protective role in myocardial ischemia and microRNAs (miRNAs) participate in many cardiac pathophysiological processes, including ischemia-induced cardiac injury. However, the role of miRNAs in M(3)-mAChR mediated cardioprotection remains unexplored. The
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