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主要文件

安全信息

M9434

Sigma-Aldrich

Anti-Myelin Basic Protein Antibody

rat monoclonal, 14

别名:

Anti-MBP

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About This Item

MDL编号:
UNSPSC代码:
12352203
NACRES:
NA.41

产品名称

Monoclonal Anti-Myelin Basic Protein (MBP) (36-50) antibody produced in rat, clone 14, tissue culture supernatant

生物来源

rat

质量水平

偶联物

unconjugated

抗体形式

tissue culture supernatant

抗体产品类型

primary antibodies

克隆

14, monoclonal

包含

0.09% sodium azide

种属反应性

horse, chicken, human

技术

ELISA: suitable
immunofluorescence: suitable
immunohistochemistry: suitable

同位素/亚型

IgG

UniProt登记号

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... MBP(4155)

一般描述

Myelin basic protein (MBP) is part of the myelin sheath and is a calcium-dependent protein. It has six isoforms and the gene encoding it is localized on human chromosome 18q23.

特异性

Recognizes amino acids 36-50 of myelin basic protein.

免疫原

bovine myelin basic protein.

生化/生理作用

Myelin basic protein (MBP) associates with calmodulin and has been identified as an auto-antigen in multiple sclerosis (MS). It also inhibits the assembly of amyloid-β protein.

制备说明

Generated by somatic cell hybridization of NS0 myeloma cells with spleen cells from an outbred rat immunized with bovine myelin basic protein.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

法规信息

常规特殊物品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Alexey Belogurov et al.
The Journal of biological chemistry, 289(25), 17758-17766 (2014-04-18)
The vast majority of cellular proteins are degraded by the 26S proteasome after their ubiquitination. Here, we report that the major component of the myelin multilayered membrane sheath, myelin basic protein (MBP), is hydrolyzed by the 26S proteasome in a
Neha Soni et al.
Frontiers in neurology, 11, 153-153 (2020-03-27)
Early loss of white matter microstructure integrity is a significant cause of long-term neurological disorders following traumatic brain injury (TBI). White matter abnormalities typically involve axonal loss and demyelination. In-vivo imaging tools to detect and differentiate such microstructural changes are
H K Palliser et al.
Neuroendocrinology, 96(1), 60-67 (2012-04-18)
Intra-uterine growth restriction (IUGR) is a significant in utero complication that can have profound effects on brain development including reduced myelination and deficits that can continue into adulthood. Progesterone increases oligodendrocyte proliferation and myelin expression, an action that may depend
Frank Rattay et al.
PloS one, 8(11), e79256-e79256 (2013-11-22)
Our knowledge about the neural code in the auditory nerve is based to a large extent on experiments on cats. Several anatomical differences between auditory neurons in human and cat are expected to lead to functional differences in speed and
Chikashi Terao et al.
PloS one, 6(6), e20457-e20457 (2011-06-16)
Rheumatoid arthritis (RA) is a major cause of adult chronic inflammatory arthritis and a typical complex trait. Although several genetic determinants have been identified, they account for only a part of the genetic susceptibility. We conducted a genome-wide association study

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