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特异性
特异性通过小鼠单克隆抗体分型试纸条测定。该纯化免疫球蛋白制品与小鼠IgA、IgM、IgG2a、IgG2b和IgG3都不具反应性。
应用
IgG1, κ（来自小鼠骨髓瘤）已用于：
- 白细胞免疫荧光，50 μg/ml浓度
- 作为酶联免疫吸附测定(ELISA)的标准品
- 通过凝胶过滤和离心技术进行置换浓缩用于荧光标记
IgG1, κ（来自鼠骨髓瘤）已用于：
- 球结膜切片的原位杂交实验
- 牛和动脉组织的免疫组化
IgG1，κ（来自小鼠骨髓瘤）已用于流式细胞分析和免疫沉淀技术。
生化/生理作用
IgG1 分子量为 146 kDa，是一种大量表达的 IgG 亚类。IgG1 缺陷导致总 IgG 水平总体下降，从而导致低丙种球蛋白血症。IgG1 促进细菌吞噬作用，介导疫苗诱导的感染保护作用。IgG2a 与 IgG1 的比例对抗热带利什曼原虫感染的免疫应答至关重要。其与 Fcγ 受体 (FcγR) 具有高结合亲和力。高水平 IgG1-κ抗体与肾小球肾炎的病理有关。
IgG抗体亚型存在于血浆和细胞外液中，提供抗细菌、真菌和病毒的保护作用。母体IgG可通过胎盘转移至胎儿，胎盘对新生儿免疫防御感染至关重要。
外形
0.02 MTris 缓冲盐溶液，pH 8.0，含 0.02% 叠氮化钠
储存及稳定性
−20 °C储存。本品可以工作等分试样的形式在-20 °C下冻存。不建议反复冻融。
免责声明
除非我们的产品目录或产品随附的其他公司文件中另有说明，否则我们的产品仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途或任何类型的人类或动物消费或应用。
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
B Steppich et al.
American journal of physiology. Cell physiology, 279(3), C578-C586 (2000-08-16)
Strenuous, anaerobic exercise leads to an increase of leukocytes that are mobilized from the marginal pool. We have analyzed in human peripheral blood the effect of exercise on the number of CD14(+)CD16(+) monocytes as determined by two-color immunofluorescence and flow
Elin Borgen et al.
Breast cancer research : BCR, 20(1), 120-120 (2018-10-17)
The presence of disseminated tumor cells (DTCs) in bone marrow (BM) is an independent prognostic factor in early breast cancer but does not uniformly predict outcome. Tumor cells can persist in a quiescent state over time, but clinical studies of
Cecilia Lässer et al.
Journal of visualized experiments : JoVE, (59), e3037-e3037 (2012-01-20)
The field of exosome research is rapidly expanding, with a dramatic increase in publications in recent years. These small vesicles (30-100 nm) of endocytic origin were first proposed to function as a way for reticulocytes to eradicate the transferrin receptor
Phillip A Doerfler et al.
Clinical immunology (Orlando, Fla.), 158(2), 140-147 (2015-04-07)
Antibodies formed against the therapeutic protein are a life-threatening complication that arises during enzyme replacement therapy for Pompe disease (acid α-glucosidase deficiency; GAA). To provide an effective alternative to current practices, we investigated the capacity of anti-B-cell activating factor (BAFF)
G G de Sá Oliveira et al.
Clinical and experimental immunology, 105(2), 313-320 (1996-08-01)
The specificities of a panel of erythrocyte-reactive MoAbs derived from NZB mice with autoimmune haemolytic anaemia (AIHA) were determined by immunoprecipitation and immunoblotting. Of the eight antibodies, two (IgG1 MoAb 105-2H and IgG2a MoAb 34-3C) immunoprecipitated a 105-kD component identified
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