一般描述
Microsomes are the fraction of "submicroscopic” particles isolated from homogenates of liver and other tissues. Microsomes are rich in ribonucleic acid (RNA).
应用
Microsomes from Liver, Pooled has been used in following studies:
- inhibition of microsomal lipid peroxidation.
- hydroxylation of isorhynchophylline (ISOR) in rats.
生化/生理作用
肝微粒体是来源于肝细胞内质网的亚细胞颗粒。这些微粒体是药物代谢酶（包括细胞色素 P-450）的丰富来源。不同来源的微粒体池有助于研究外源代谢和药物相互作用。
Microsomes might act as cell organelles and are actively involved in protein synthesis. Carbon monoxide-binding pigment of microsomes, named P-450, is an integral element of mixed function oxidase systems involved in the oxidative demethylation and hydroxylation of drugs and steroids. Murine liver microsomes plays a crucial role in degradation of small antimicrobial β2,2-amino acid derivatives.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
动植物源性产品
Liver microsomes; an integrated morphological and biochemical study.
PALADE GE
The Journal of Biophysical and Biochemical Cytology, 2(2), 171-200 (1956)
Xiaofei Zhang et al.
ACS chemical neuroscience, 8(9), 1937-1948 (2017-06-02)
Metabotropic glutamate 2 receptors (mGlu
Role of hemoprotein P-450 in fatty acid omega-hydroxylation in a soluble enzyme system from liver microsomes.
Lu AY and Coon MJ
The Journal of Biological Chemistry, 243(6), 1331-1332 (1968)
Metabolism of isorhynchophylline in rats detected by LC-MS.
Wang W
J. Pharm. Pharm. Sci., 13(1), 27-37 (2010)
Michele Gottardi et al.
Aquatic toxicology (Amsterdam, Netherlands), 201, 11-20 (2018-06-03)
Azole fungicides, designed to halt fungal growth by specific inhibition of fungal cytochrome P450 (CYP51), inhibit cytochrome P450s involved in the metabolism of xenobiotics in several non-target organisms thus raising environmental concern. The present study investigates the degree by which
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