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生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
MCR54, monoclonal
形式
buffered aqueous solution
分子量
antigen ~150 kDa
种属反应性
human
包装
antibody small pack of 25 μL
浓度
~2.0 mg/mL
技术
western blot: 2.5-5 μg/mL using HEK-293T cells overexpressing myocardin
同位素/亚型
IgG2b
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... MYOCD(93649)
一般描述
Monoclonal Anti-Myocardin (mouse IgG2b isotype) is derived from the hybridoma MCR54 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of human myocardin. Myocardin (MYOCD) is a transcriptional coactivator.
Myocardin (MYOCD) is expressed in the muscles and cardiomyocytes. It is a co-transcriptional factor.
应用
Monoclonal Anti-Myocardin antibody produced in mouse has been used in western blot analysisimmunofluorescence.
生化/生理作用
Myocardin (MYOCD) takes part in the differentiation of vascular smooth muscle cells (VSMC). It is a co-factor of serum response factor (SRF) and regulates the activation of those genes which are dependent on SRF. MYOCD forms a complex with SRF on DNA.
Myocardin is a smooth and cardiac muscle-specific transcriptional coactivator of serum response factor (SRF). It regulates the expression of a set of cardiac and smooth muscle-specific genes. Myocardin was implicated in the pathogenesis of atherosclerosis, Alzheimer′s disease, and malignant transformation.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 2
法规信息
常规特殊物品
Myocardin in biology and disease
Miano JM
Journal of biomedical research, 29(1), 3-3 (2015)
Fibroblast growth factor 12 is a novel regulator of vascular smooth muscle cell plasticity and fate
Song SH, et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 36(9), 1928-1936 (2016)
The serum response factor coactivator myocardin is required for vascular smooth muscle development
Li S, et al.
Proceedings of the National Academy of Sciences of the USA, 100(16), 9366-9370 (2003)
Pavneet Singh et al.
PloS one, 9(11), e112120-e112120 (2014-11-11)
De-differentiation of vascular smooth muscle cells (VSMCs) plays a critical role in the development of atherosclerosis, a chronic inflammatory disease involving various cytokines such as tumor necrosis factor-α (TNFα). Myocardin is a co-factor of serum response factor (SRF) and is
Linda Raphel et al.
PloS one, 7(8), e44052-e44052 (2012-09-01)
Myocardin is thought to have a key role in smooth muscle cell (SMC) development by acting on CArG-dependent genes. However, it is unclear whether myocardin-induced SMC maturation and increases in agonist-induced calcium signalling are also associated with increases in the
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