M8750

(+)-甲基苯丙胺盐酸盐

Name: (+)-甲基苯丙胺 盐酸盐
Brand: SIGMA

别名:

d-Desoxyephedrine hydrochloride, d-N,α-Dimethylphenethylamine hydrochloride, Methylamphetamine hydrochloride

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经验公式（希尔记法）:

C₁₀H₁₅N · HCl

化学文摘社编号:

51-57-0

分子量:

185.69

NACRES:

NA.77

PubChem Substance ID:

24897282

UNSPSC Code:

12352116

EC Number:

200-106-9

MDL number:

MFCD00056130

主要文件

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InChI key

TWXDDNPPQUTEOV-FVGYRXGTSA-N

InChI

1S/C10H15N.ClH/c1-9(11-2)8-10-6-4-3-5-7-10;/h3-7,9,11H,8H2,1-2H3;1H/t9-;/m0./s1

SMILES string

Cl[H].CN[C@@H](C)Cc1ccccc1

Quality Level

200

Gene Information

human ... SLC6A2(6530), SLC6A3(6531), SLC6A4(6532)

drug control

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IIB (Portugal); Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet
kontrollierte Droge in Deutschland

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

solubility

H₂O: soluble
ethanol: soluble

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

originator

Teva

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Biochem/physiol Actions

Sympathomimetic with more potent central effects than amphetamine. It is transported into terminals via the monoamine transporters and induces release of dopamine, norepinephrine, epinephrine, and serotonin. Dopamine release is important for the addictive properties of methamphetamine while norepinephrine and epinephrine release are important for the cardiovascular effects. Serotonin neurotoxin.

Features and Benefits

This compound was developed by Teva. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

pictograms

GHS06

signalword

Danger

hcodes

H300,H336

pcodes

P301 + P310 + P330

Hazard Classifications

Acute Tox. 2 Oral - STOT SE 3

target_organs

Central nervous system

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

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Effects of berberine hydrochloride on methamphetamine-induced anxiety behaviors and relapse in rats.

Leila Rezaeian et al.

Iranian journal of basic medical sciences, 23(11), 1480-1488 (2020-11-26)

This research aimed at evaluating the effect of berberine hydrochloride on anxiety-related behaviors induced by methamphetamine (METH) in rats, assessing relapse and neuroprotective effects. 27 male Wistar rats were randomly assigned into groups of Control, METH-withdrawal (METH addiction and subsequent

Spontaneous locomotor activity and pharmacokinetics of intravenous methamphetamine and its metabolite amphetamine in the rat.

G J Rivière et al.

The Journal of pharmacology and experimental therapeutics, 291(3), 1220-1226 (1999-11-24)

The purpose of these studies was to better understand the behavioral effects and pharmacokinetics of an i.v. bolus dose of (+)-methamphetamine [(+)-METH] in a rat model of (+)-METH abuse. We characterized the behavioral effects after increasing (+)-METH doses (0.1, 0.3

Non-genetic factors that influence methamphetamine intake in a genetic model of differential methamphetamine consumption.

A M Stafford et al.

Psychopharmacology, 237(11), 3315-3336 (2020-08-25)

Genetic and non-genetic factors influence substance use disorders. Our previous work in genetic mouse models focused on genetic factors that influence methamphetamine (MA) intake. The current research examined several non-genetic factors for their potential influence on this trait. We examined

The C-Terminal Domain of LRRK2 with the G2019S Substitution Increases Mutant A53T α-Synuclein Toxicity in Dopaminergic Neurons In Vivo.

Noémie Cresto et al.

International journal of molecular sciences, 22(13) (2021-07-03)

Alpha-synuclein (α-syn) and leucine-rich repeat kinase 2 (LRRK2) play crucial roles in Parkinson's disease (PD). They may functionally interact to induce the degeneration of dopaminergic (DA) neurons via mechanisms that are not yet fully understood. We previously showed that the

Methamphetamine Activates Toll-Like Receptor 4 to Induce Central Immune Signaling within the Ventral Tegmental Area and Contributes to Extracellular Dopamine Increase in the Nucleus Accumbens Shell.

Xiaohui Wang et al.

ACS chemical neuroscience, 10(8), 3622-3634 (2019-07-10)

Methamphetamine (METH) is a globally abused, highly addictive stimulant. While investigations of the rewarding and motivational effects of METH have focused on neuronal actions, increasing evidence suggests that METH can also target microglia, the innate immune cells of the central

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(+)-甲基苯丙胺 盐酸盐

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关于此项目

主要文件

属性

InChI key

InChI

SMILES string

Quality Level

Gene Information

drug control

technique(s)

solubility

application(s)

originator

相关类别

说明

Biochem/physiol Actions

Features and Benefits

Other Notes

Legal Information

安全信息

pictograms

signalword

hcodes

pcodes

Hazard Classifications

target_organs

存储类别

wgk

flash_point_f

flash_point_c

ppe

法规信息

文件

分析证书(COA)

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(+)-甲基苯丙胺盐酸盐