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Merck
CN
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文件

安全信息

M8750

Sigma-Aldrich

(+)-甲基苯丙胺 盐酸盐

别名:

d-Desoxyephedrine hydrochloride, d-N,α-Dimethylphenethylamine hydrochloride, Methylamphetamine hydrochloride

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About This Item

经验公式（希尔记法）:
C10H15N · HCl
CAS号:
51-57-0
分子量:
185.69
EC 号:
200-106-9
MDL编号:
MFCD00056130
UNSPSC代码:
12352116
PubChem化学物质编号:
24897282
NACRES:
NA.77

质量水平

200

药品控制

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IIB (Portugal)

技术

HPLC: suitable
gas chromatography (GC): suitable

溶解性

H2O: soluble
ethanol: soluble

应用

forensics and toxicology
pharmaceutical (small molecule)
veterinary

创始人

Teva

SMILES字符串

Cl[H].CN[C@@H](C)Cc1ccccc1

InChI

1S/C10H15N.ClH/c1-9(11-2)8-10-6-4-3-5-7-10;/h3-7,9,11H,8H2,1-2H3;1H/t9-;/m0./s1

InChI key

TWXDDNPPQUTEOV-FVGYRXGTSA-N

基因信息

human ... SLC6A2(6530) , SLC6A3(6531) , SLC6A4(6532)

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相关类别

生化/生理作用

Sympathomimetic with more potent central effects than amphetamine. It is transported into terminals via the monoamine transporters and induces release of dopamine, norepinephrine, epinephrine, and serotonin. Dopamine release is important for the addictive properties of methamphetamine while norepinephrine and epinephrine release are important for the cardiovascular effects. Serotonin neurotoxin.

特点和优势

This compound was developed by Teva. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

其他说明

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H300,H336

预防措施声明

P301 + P310 + P330

危险分类

Acute Tox. 2 Oral - STOT SE 3

靶器官

Central nervous system

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

新产品

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Noémie Cresto et al.
International journal of molecular sciences, 22(13) (2021-07-03)
Alpha-synuclein (α-syn) and leucine-rich repeat kinase 2 (LRRK2) play crucial roles in Parkinson's disease (PD). They may functionally interact to induce the degeneration of dopaminergic (DA) neurons via mechanisms that are not yet fully understood. We previously showed that the
Kaveh Shahveisi et al.
Pharmacology, biochemistry, and behavior, 185, 172759-172759 (2019-08-16)
Susceptibility to interference can be a result of memory retrieval and reconsolidation. Given the fact that addiction develops through the neural mechanisms of learning and memory, it would not be surprising that a consolidated drug reward memory may also be
Arkadiusz Liśkiewicz et al.
Brain, behavior, and immunity, 80, 247-254 (2019-03-20)
Methamphetamine (METH) abusers are prone to develop a variety of comorbidities, including cognitive disabilities, and the immunological responses have been recognized as an important component involved in the toxicity of this drug. Cytokines are among the key mediators between systemic
Xiaohui Wang et al.
ACS chemical neuroscience, 10(8), 3622-3634 (2019-07-10)
Methamphetamine (METH) is a globally abused, highly addictive stimulant. While investigations of the rewarding and motivational effects of METH have focused on neuronal actions, increasing evidence suggests that METH can also target microglia, the innate immune cells of the central
Leila Rezaeian et al.
Iranian journal of basic medical sciences, 23(11), 1480-1488 (2020-11-26)
This research aimed at evaluating the effect of berberine hydrochloride on anxiety-related behaviors induced by methamphetamine (METH) in rats, assessing relapse and neuroprotective effects. 27 male Wistar rats were randomly assigned into groups of Control, METH-withdrawal (METH addiction and subsequent
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