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Merck
CN
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文件

安全信息

M8693

Sigma-Aldrich

Melanotan II 乙酸盐

≥95% (HPLC)

别名:

Ac-[Nle4Asp5D-Phe7Lys10]α-MSH-(4-10)-NH2

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About This Item

经验公式（希尔记法）:
C50H69N15O9 · xC2H4O2
CAS号:
121062-08-6
分子量:
1024.18 (free base basis)
MDL编号:
MFCD06795842
UNSPSC代码:
51111800
NACRES:
NA.32

质量水平

200

检测方案

≥95% (HPLC)

形式

lyophilized solid

颜色

white

溶解性

H2O: soluble 5 mg/mL

运输

dry ice

储存温度

−20°C

InChI

1S/C50H69N15O9/c1-3-4-16-36(59-29(2)66)44(69)65-41-25-42(67)55-20-11-10-18-35(43(51)68)60-47(72)39(23-31-26-57-34-17-9-8-15-33(31)34)63-45(70)37(19-12-21-56-50(52)53)61-46(71)38(22-30-13-6-5-7-14-30)62-48(73)40(64-49(41)74)24-32-27-54-28-58-32/h5-9,13-15,17,26-28,35-41,57H,3-4,10-12,16,18-25H2,1-2H3,(H2,51,68)(H,54,58)(H,55,67)(H,59,66)(H,60,72)(H,61,71)(H,62,73)(H,63,70)(H,64,74)(H,65,69)(H4,52,53,56)/t35-,36-,37-,38+,39-,40-,41-/m0/s1

InChI key

JDKLPDJLXHXHNV-MFVUMRCOSA-N

基因信息

human ... MC3R(4159) , MC4R(4160)
mouse ... MC3R(17201) , MC4R(17202)
rat ... MC3R(29310) , MC4R(25635)

Amino Acid Sequence

Ac-Nle-Asp-His-Phe-Arg-Trp-Lys-NH2

一般描述

Melanotan II诱导黑色素生成，从而增加皮肤色素沉着。是α-黑素细胞刺激素的类似物。

应用

Melanotan II乙酸盐已被用于研究其对大鼠进食和能量消耗的抑制作用。

生化/生理作用

Melanotan II 是一种 MC3-R/MC4-R 黑皮质素激动剂。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

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Y B Shrestha et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 299(1), R140-R149 (2010-04-23)
Norepinephrine (NE) released from the sympathetic nerves innervating white adipose tissue (WAT) is the principal initiator of lipolysis in mammals. Central WAT sympathetic outflow neurons express melanocortin 4-receptor (MC4-R) mRNA. Single central injection of melanotan II (MTII; MC3/4-R agonist) nonuniformly
Yi Zhang et al.
Peptides, 31(4), 639-643 (2009-12-26)
Central melanocortins (MC) evoke potent but transient anorectic responses with tachyphylaxis developing within days. We hypothesized that intermittent therapy using the MC analog, melanotan II (MTII), would minimize the tachyphylaxis and enhance the long-term efficacy of MTII treatment. F344/BN rats
Ki Sung Kang et al.
Peptides, 32(1), 31-35 (2010-10-20)
Intracerebroventricular (ICV) administration of gonadotropin-releasing hormone II (GnRH II), which plays a crucial role in the regulation of reproduction in vertebrates, markedly reduces food intake in goldfish. However, the neurochemical pathways involved in the anorexigenic action of GnRH II and
Mesoporous silicon microparticles as carriers for peptides.
M Kilpeläinen et al.
Journal of controlled release : official journal of the Controlled Release Society, 148(1), e43-e44 (2011-05-03)
Miia Kilpeläinen et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 77(1), 20-25 (2010-10-23)
Peptide molecules can improve the treatment of a number of pathological conditions, but due to their physicochemical properties, their delivery is very challenging. The study aim was to determine whether nanostructured porous silicon could sustain the release and prolong the
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