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一般描述
黑色素是存在于脊椎动物表面结构中的重要色素，可导致皮肤变色。它具有三种形式，如：真黑素(eumelanin)，褐黑素(pheomelanin)，神经黑素(neuromelanin)。黑色素具有阳离子螯合和氧化还原特性。它是强效的光吸收剂。黑色素起化学保护和光保护性颜料的作用。该基因的突变与眼白化病、白癜风、花斑病和瓦登伯格综合征有关。
应用
黑色素已用于：
- 分光光度法测定
- 研究其对逆转录聚合酶链式反应(RT-PCR)的抑制作用以及BSA（牛血清白蛋白）在克服抑制作用方面的作用
- 用作近红外组织光谱中皮肤层的吸收剂
- 拉曼光谱分析
制备说明
通过使用过氧化氢对酪氨酸进行氧化制备。
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Zheng Wang et al.
Frontiers in microbiology, 4, 379-379 (2014-01-01)
Melanization due to the inactivation of the homogentisate-1,2-dioxygenase gene (hmgA) has been demonstrated to increase stress resistance, persistence, and virulence in some bacterial species but such pigmented mutants have not been observed in pathogenic members of the Vibrio Harveyi clade.
Danielle J Harper et al.
Journal of biophotonics, 12(12), e201900153-e201900153 (2019-07-25)
Previous studies for melanin visualization in the retinal pigment epithelium (RPE) have exploited either its absorption properties (using photoacoustic tomography or photothermal optical coherence tomography [OCT]) or its depolarization properties (using polarization sensitive OCT). However, these methods are only suitable
Fengmei Zou et al.
Biomedical optics express, 1(3), 748-761 (2011-01-25)
An accurate SO(2) prediction method for using broadband continuous-wave diffuse reflectance near infrared (NIR) spectroscopy is proposed. The method fitted the NIR spectra to a Taylor expansion attenuation model, and used the simulated annealing method to initialize the nonlinear least
Justyna M Drewnowska et al.
PloS one, 10(4), e0125428-e0125428 (2015-04-25)
Although melanin is known for protecting living organisms from harmful physical and chemical factors, its synthesis is rarely observed among endospore-forming Bacillus cereus sensu lato. Here, for the first time, we reported that psychrotolerant Bacillus weihenstephanensis from Northeastern Poland can
Diorders of Pigmentation
Zaidi Z, et al.
Treatment of Skin Diseases, 159-170 (2019)
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