所有图片(2)
About This Item
经验公式（希尔记法）:
C14H16N2O3S
CAS号:
分子量:
292.35
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
质量水平
方案
≥98% (HPLC)
表单
solid
储存条件
protect from light
颜色
white to off-white
mp
185-185.9 °C (lit.)
溶解性
DMSO: >5 mg/mL
储存温度
2-8°C
SMILES字符串
CCOC(=O)C1=C(C)NC(=S)NC1c2cccc(O)c2
InChI
1S/C14H16N2O3S/c1-3-19-13(18)11-8(2)15-14(20)16-12(11)9-5-4-6-10(17)7-9/h4-7,12,17H,3H2,1-2H3,(H2,15,16,20)
InChI key
LOBCDGHHHHGHFA-UHFFFAOYSA-N
应用
Monastrol已被用于：
- 将MDA-MB-231细胞作为非微管靶向剂
- 作为抗肿瘤剂，治疗小鼠骨髓瘤细胞系SP 2/0，诱导细胞凋亡并阐明代谢型谷氨酸受体3（Grm3）在凋亡中的作用-作为蝶呤还原酶抑制剂在GFP转染的前鞭毛体巨噬细胞中的作用
- 用于基于流式细胞仪的生长抑制试验并评价利什曼原虫仓鼠体内模型的抗利什曼活性
生化/生理作用
Monastrol 是一种强效、细胞渗透的有丝分裂抑制剂。Monastrol 阻滞细胞的特征是单极纺锤体。该表型是通过用 IC 50 在 14μM的浓度下特异性破坏有丝分裂分子马达驱动蛋白 Eg5 而诱导的。对其他马达蛋白和微管蛋白无影响。
特点和优势
这种化合物是凋亡研究的特色产品。点击此处发现更多特色凋亡产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
包装
在惰性气体下包装。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Renske van Leuken et al.
PloS one, 4(4), e5282-e5282 (2009-04-25)
Polo-like kinase-1 (Plk1) is activated before mitosis by Aurora A and its cofactor Bora. In mitosis, Bora is degraded in a manner dependent on Plk1 kinase activity and the E3 ubiquitin ligase SCF-betaTrCP. Here, we show that Plk1 is also
Steven Haney et al.
PloS one, 8(6), e64946-e64946 (2013-07-11)
Genome-wide association (GWA) studies have described a large number of new candidate genes that contribute to of Type 2 Diabetes (T2D). In some cases, small clusters of genes are implicated, rather than a single gene, and in all cases, the
T U Mayer et al.
Science (New York, N.Y.), 286(5441), 971-974 (1999-11-05)
Small molecules that perturb specific protein functions are valuable tools for dissecting complex processes in mammalian cells. A combination of two phenotype-based screens, one based on a specific posttranslational modification, the other visualizing microtubules and chromatin, was used to identify
Rebecca A Holton et al.
Biology of reproduction, 103(1), 24-35 (2020-03-29)
The number and quality of oocytes, as well as the decline in both of these parameters with age, determines reproductive potential in women. However, the underlying mechanisms of this diminution are incompletely understood. Previously, we identified novel roles for CHTF18
Metabotropic glutamate receptor 3 is involved in B-cell-related tumor apoptosis
Liu X, et al.
International journal of oncology, 49(4), 1469-1478 (2016)
商品
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.
Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
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