M8515
莫纳托
≥98% (HPLC), Mitosis inhibitor, solid
别名:
4-（3-羟基苯基）-6-甲基-2-硫氧-1,2,3,4-四氢-4H-嘧啶-5-羧酸乙酯
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关于此项目
经验公式（希尔记法）:
C14H16N2O3S
化学文摘社编号:
分子量:
292.35
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
莫纳托, ≥98% (HPLC), solid
Quality Level
assay
≥98% (HPLC)
form
solid
storage condition
protect from light
color
white to off-white
mp
185-185.9 °C (lit.)
solubility
DMSO: >5 mg/mL
storage temp.
2-8°C
SMILES string
CCOC(=O)C1=C(C)NC(=S)NC1c2cccc(O)c2
InChI
1S/C14H16N2O3S/c1-3-19-13(18)11-8(2)15-14(20)16-12(11)9-5-4-6-10(17)7-9/h4-7,12,17H,3H2,1-2H3,(H2,15,16,20)
InChI key
LOBCDGHHHHGHFA-UHFFFAOYSA-N
Application
Monastrol已被用于：
- 将MDA-MB-231细胞作为非微管靶向剂
- 作为抗肿瘤剂，治疗小鼠骨髓瘤细胞系SP 2/0，诱导细胞凋亡并阐明代谢型谷氨酸受体3（Grm3）在凋亡中的作用-作为蝶呤还原酶抑制剂在GFP转染的前鞭毛体巨噬细胞中的作用
- 用于基于流式细胞仪的生长抑制试验并评价利什曼原虫仓鼠体内模型的抗利什曼活性
Biochem/physiol Actions
Monastrol 是一种强效、细胞渗透的有丝分裂抑制剂。Monastrol 阻滞细胞的特征是单极纺锤体。该表型是通过用 IC 50 在 14μM的浓度下特异性破坏有丝分裂分子马达驱动蛋白 Eg5 而诱导的。对其他马达蛋白和微管蛋白无影响。
Features and Benefits
这种化合物是凋亡研究的特色产品。点击此处发现更多特色凋亡产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
Packaging
在惰性气体下包装。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
商品
Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.
T U Mayer et al.
Science (New York, N.Y.), 286(5441), 971-974 (1999-11-05)
Small molecules that perturb specific protein functions are valuable tools for dissecting complex processes in mammalian cells. A combination of two phenotype-based screens, one based on a specific posttranslational modification, the other visualizing microtubules and chromatin, was used to identify
Mayumi Kitagawa et al.
PloS one, 8(6), e64826-e64826 (2013-06-12)
Although Aurora B is important in cleavage furrow ingression and completion during cytokinesis, the mechanism by which kinase activity is targeted to the cleavage furrow and the molecule(s) responsible for this process have remained elusive. Here, we demonstrate that an
Renske van Leuken et al.
PloS one, 4(4), e5282-e5282 (2009-04-25)
Polo-like kinase-1 (Plk1) is activated before mitosis by Aurora A and its cofactor Bora. In mitosis, Bora is degraded in a manner dependent on Plk1 kinase activity and the E3 ubiquitin ligase SCF-betaTrCP. Here, we show that Plk1 is also
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| M8515-5MG | 04061833066171 |
| M8515-1MG | 04061826676189 |