产品名称
抗-MCH 兔抗, IgG fraction of antiserum, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
indirect ELISA: 1:2,500
microarray: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PMCH(5367)
Immunogen
对应于与KLH结合的人黑色素浓缩激素的合成肽。MCH序列在许多物种中是相同的，包括大鼠，小鼠和猪。
Physical form
磷酸盐缓冲盐水溶液，含有15 mM叠氮化钠。
Application
兔产生的抗MCH抗体可用于放射免疫测定和免疫组化。
抗MCH抗体可以1：30000的工作稀释度用于RIA。对于小鼠下丘脑切片的免疫组化，可使用1：200的工作抗体稀释度。该抗体已用于浓度为5.7 μg/ml的T细胞细胞质提取物中的免疫印迹。该抗体适用于蛋白质微阵列。
Biochem/physiol Actions
MCH mRNA在禁食期间在ob/ob小鼠和大鼠的下丘脑中过表达和上调。 大鼠侧脑室注射MCH可促进摄食量增加。此外，缺乏MCH基因的基因敲除小鼠瘦弱且吞咽不足，并表现出代谢率的增加。相比之下，转基因小鼠中MCH的过度表达导致肥胖和胰岛素抵抗。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
黑色素浓缩激素（MCH）是存在于下丘脑中的循环19个氨基酸残基的环状神经肽。在哺乳动物中，MCH是由前体促黑色素浓缩激素（PMCH）编码的。它首先在鱼类中发现，随后在哺乳动物（大鼠）中发现。MCH核周体主要局限于下丘脑外侧区域（LHA）和相邻的未定带，在整个大脑中具有广泛的神经元投射。在基底神经节，新皮层，小脑，胸腺，棕色脂肪组织，十二指肠和睾丸中检测到MCH。MCH的结构在物种间是高度保守的。
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
N Kakava-Georgiadou et al.
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Targeting specific neuronal cell types is a major challenge for unraveling their function and utilizing specific cells for gene therapy strategies. Viral vector tools are widely used to target specific cells or circuits for these purposes. Here, we use viral
Electrophysiological effects of MCH on neurons in the hypothalamus
Gao XB
Peptides, 30(11), 2025-2030 (2009)
Xuan Thang Pham et al.
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Mice lacking melanin-concentrating hormone are hypophagic and lean
Shimada M, et al.
Nature, 396(6712), 670-670 (1998)
Gabriel E Bertolesi et al.
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