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Merck
CN

M8439

SAFC

L-甲硫氨酸

制药生产

别名:

L-2-氨基-4-(甲硫基)丁酸, (S)-2-氨基-4-(甲巯基)丁酸

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About This Item

线性分子式:
CH3SCH2CH2CH(NH2)CO2H
CAS号:
分子量:
149.21
Beilstein:
1722294
EC 号:
MDL编号:
UNSPSC代码:
12352209
eCl@ss:
32160406
NACRES:
NA.26

生物来源

non-animal source

质量水平

检测方案

≥99%

形式

powder

技术

cell culture | mammalian: suitable

杂质

endotoxin, heavy metals, trace metals, residual solvents, tested

mp

284 °C (dec.) (lit.)

溶解性

H2O: 50 mg/mL

适用性

suitable for manufacturing use

应用

pharmaceutical (small molecule)

异质活性

cytotoxicity, tested

SMILES字符串

CSCC[C@H](N)C(O)=O

InChI

1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1

InChI key

FFEARJCKVFRZRR-BYPYZUCNSA-N

基因信息

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一般描述

如需获取此产品的相关文档,请联系客户支持并选择“产品文档”。请注意,需要签署保密协议才能获取该产品相关文档。
我们用于生物制药加工的SAFC® 系列优质原料经过严格的质量控制流程,配合记录文件和技术专长帮助我们的客户达到M-Clarity Program规定的要求。

M-Clarity Program

我们全面的上游工艺化学品系列不仅为生物制药生产商提供生产传统和创新治疗药物所需的优质原料,而且帮助他们更快地将产品投放市场并简化监管问题。请相信我们能够为您带来透明的供应链和可靠的全球采购能力,以最佳的法规支持和服务简化您的产品认证。

应用

L-蛋氨酸是一种必需氨基酸。 它被作为细胞培养基成分用于治疗性重组蛋白和单克隆抗体的商业化生物制造。

法律信息

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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Ronald O Ball et al.
The Journal of nutrition, 136(6 Suppl), 1682S-1693S (2006-05-17)
Sulfur amino acid metabolism has been receiving increased attention because of the link to chronic diseases such as cardiovascular disease, Alzheimer's disease, and diabetes. In addition, the role of cysteine and optimal intakes for physiological substrates such as glutathione are
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BMC medical genetics, 14, 106-106 (2013-10-10)
Methionyl-tRNA synthetase (MARS) catalyzes the ligation of methionine to its cognate transfer RNA and therefore plays an essential role in protein biosynthesis. We used exome sequencing, aminoacylation assays, homology modeling, and immuno-isolation of transfected MARS to identify and characterize mutations
Olga Z Karicheva et al.
Nucleic acids research, 39(18), 8173-8186 (2011-07-05)
Mutations in human mitochondrial DNA are often associated with incurable human neuromuscular diseases. Among these mutations, an important number have been identified in tRNA genes, including 29 in the gene MT-TL1 coding for the tRNA(Leu(UUR)). The m.3243A>G mutation was described
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Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(5), 739-747 (2013-04-05)
All patients with primary hyperparathyroidism should undergo localization studies before reoperation, but it is not known which method is most accurate. The purpose of this prospective study was to compare the performance of planar scintigraphy with (123)I/(99m)Tc-sestamibi, (99m)Tc-sestamibi SPECT (SPECT/CT)

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