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生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
35509.11, monoclonal
形式
lyophilized powder
种属反应性
human
技术
indirect ELISA: suitable
neutralization: suitable
western blot: suitable
同位素/亚型
IgG1
UniProt登记号
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CCL8(6355)
一般描述
Monocyte Chemotactic Protein-2 (MCP-2) belongs to a family of C-C chemotactic cytokines. MCP-1, -3, -4, and -5 are the other five monocyte chemo attractants identified. The MCP cytokines are involved in recruitment of leukocytes to the sites of inflammation, and activate NK cells and CD4+ and CD8+ T lymphocytes. Additionally, MCP cytokines can activate basophils to secrete histamines and also attract eosinophils. MCPs play an important role in pathological conditions such as systemic sclerosis, myocardia and cardiac ischemia. Anti-monocyte chemotactic protein 2 antibody specifically reacts with human MCP-2. The antibody shows <20% cross reactivity with recombinant human MCP-1 and recombinant mouse MIP-1α.
特异性
Neutralizes the biological activity of recombinant human MCP-2. Shows <20% cross-reactivity with recombinant human MCP-1 and recombinant mouse MIP-1α.
免疫原
recombinant human MCP-2 expressed in E. coli.
应用
Monoclonal Anti-Monocyte Chemotactic Protein-2 antibody may be used in ELISA at a concentration of 2.0 μg/ml. For immunoblotting a working concentration of 1-2 μg/ml may be used. The antibody is suitable for neutralization reactions; ND50 is 1-4 μg/ml.
外形
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5% trehalose
制备说明
Purified using protein A.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
J H W Distler et al.
Rheumatology (Oxford, England), 48(2), 98-103 (2008-11-06)
Activation of the immune system and increased synthesis of extracellular matrix proteins by fibroblasts are hallmarks in the pathogenesis of SSc. The molecular mechanisms underlying the infiltration of inflammatory cells into the skin and the subsequent activation of fibroblasts are
Jianli Niu et al.
Clinical science (London, England : 1979), 117(3), 95-109 (2009-07-02)
Many of the major diseases, including cardiovascular disease, are widely recognized as inflammatory diseases. MCP-1 (monocyte chemotactic protein-1) plays a critical role in the development of cardiovascular diseases. MCP-1, by its chemotactic activity, causes diapedesis of monocytes from the lumen
I Clark-Lewis et al.
Journal of leukocyte biology, 57(5), 703-711 (1995-05-01)
Structural analysis of chemokines has revealed that the alpha/beta structural-fold is highly conserved among both the CXC and CC chemokine classes. Although dimerization and aggregation is often observed, the chemokines function as monomers. The critical receptor binding regions are in
M Weber et al.
Journal of immunology (Baltimore, Md. : 1950), 154(8), 4166-4172 (1995-04-15)
It has been shown that CC chemokines activate basophil and eosinophil leukocytes with different selectivities and patterns of activity. The most effective are monocyte chemotactic protein-1 (MCP-1), a potent stimulus of mediator release in basophils without effects on eosinophils, RANTES
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