推荐产品
应用
米诺地尔硫酸盐(MXS)已用于研究其作为药物，对促肾上腺皮质激素释放因子过表达(CRF-OE)小鼠脱发的治疗作用。它也已用作某项检测的阳性对照，用于培养大鼠触须毛囊。
生化/生理作用
米诺地尔硫酸盐(MXS)是米诺地尔的内源性衍生物。水溶性更高，是强效的血管扩张剂。米诺地尔硫酸盐可治疗雄激素性秃发或男性型秃发。
特点和优势
该化合物由 Johnson & Johnson 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单，请单击此处。
其他说明
米诺地尔的活性代谢产物。
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
G M Pacifici et al.
European journal of clinical pharmacology, 45(4), 337-341 (1993-01-01)
Minoxidil requires to be sulphated to exert its hypotensive effect. We report on interindividual variability in the rate of minoxidil sulphation in 118 specimens of human liver and in platelets obtained from 100 healthy subjects and 100 newborns. The frequency
Sang-Cheol Kim et al.
Archives of pharmacal research, 35(8), 1495-1503 (2012-09-04)
This study was conducted to evaluate the effect of Acanthopanax koreanum and acankoreoside J from A. koreanum on the promotion of hair growth. When immortalized rat vibrissa dermal papilla cells were treated with extract of A. koreanum leaves, the proliferation
U Russ et al.
British journal of pharmacology, 122(6), 1119-1126 (1997-12-24)
1. The ATP-sensitive K+ channel (KATP channel) in A10 cells, a cell line derived from rat thoracic aorta, was characterized by binding studies with the tritiated KATP channel opener, [3H]-P1075, and by electrophysiological techniques. 2. Saturation binding experiments gave a
R Diem et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 21(6), 2058-2066 (2001-03-14)
Tumor-necrosis-factor-alpha (TNF-alpha) prevented secondary death of retinal ganglion cells (RGCs) after axotomy of the optic nerve in vivo. This RGC rescue was confirmed in vitro in a mixed retinal culture model. In accordance with our previous findings, TNF-alpha decreased outward
K Bray et al.
Naunyn-Schmiedeberg's archives of pharmacology, 345(2), 244-250 (1992-02-01)
The effects of the K+ channel blockers tedisamil and glibenclamide on cromakalim- and minoxidil sulphate-induced 42K+ and 86Rb+ efflux and vasorelaxation in rat aorta, were investigated. In aortic strips preloaded with 42K+ or 86Rb+, cromakalim (1 mumol/l) induced increases in
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