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Merck
CN
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文件

安全信息

M7694

Sigma-Aldrich

莫匹罗星

≥92% (HPLC), powder

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别名:
5,9-Anhydro-2,3,4,8-tetradeoxy-8-[[3-(2-hydroxy-1-methylpropyl)oxiranyl]methyl]-3-methyl-[2E,8[2S,3S(1S,2S)]]-L-talonon-2-enonic acid 8-carboxyoctyl ester, BRL 4910A, Pseudomonic acid
经验公式（希尔记法）:
C26H44O9
CAS号:
12650-69-0
分子量:
500.62
MDL编号:
MFCD01711620
UNSPSC代码:
12352200
PubChem化学物质编号:
24724542
NACRES:
NA.77

质量水平

100

检测方案

≥92% (HPLC)

形式

powder

旋光性

[α]/D -15.7 to -20°, c = 1 in methanol

颜色

white to tan

溶解性

DMSO: ≥10 mg/mL

抗生素抗菌谱

fungi

作用机制

enzyme | inhibits
protein synthesis | interferes

创始人

GlaxoSmithKline

储存温度

room temp

SMILES字符串

[H][C@@]1(CO[C@@H](C\C(C)=C\C(=O)OCCCCCCCCC(O)=O)[C@H](O)[C@@H]1O)C[C@@H]2O[C@@]2([H])[C@@H](C)[C@H](C)O

InChI

1S/C26H44O9/c1-16(13-23(30)33-11-9-7-5-4-6-8-10-22(28)29)12-20-25(32)24(31)19(15-34-20)14-21-26(35-21)17(2)18(3)27/h13,17-21,24-27,31-32H,4-12,14-15H2,1-3H3,(H,28,29)/b16-13+/t17-,18-,19-,20-,21-,24+,25-,26-/m0/s1

InChI key

MINDHVHHQZYEEK-HBBNESRFSA-N

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相关类别

一般描述

Mupirocin is produced by Pseudomonas fluorescens. Mupirocin is used to treat impetigo and skin infections.

应用

Mupirocin has been used:
  • for kinetic assay
  • to assess its resistance by performing turbidity assay
  • to determine its antimicrobial susceptibility

生化/生理作用

Antibiotic; inhibits isoleucyl-tRNA synthetase (IRS).

特点和优势

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

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Eduardo Pérez-Roth et al.
Antimicrobial agents and chemotherapy, 54(5), 2252-2257 (2010-03-10)
We have sequenced the conjugative plasmid pPR9, which carries the ileS2 gene, which had contributed to the dissemination of high-level mupirocin resistance at our institution. The plasmid backbone shows extensive genetic conservation with plasmids belonging to the pSK41/pGO1 family, but
Mupirocin: a topical antibiotic with a unique structure and mechanism of action.
Parenti MA, et al.
Clinical Pharmacy, 6(10), 761-770 (1987)
Canine and Feline Dermatology Drug Handbook (2012)
Methods for detecting microbial methane production and consumption by gas chromatography
Aldridge JT, et al.
Bio-protocol, 6(7), 761-770 (2016)
Efficacy of topically delivered moxifloxacin against wound infection by Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus
Jacobsen F, et al.
Antimicrobial Agents and Chemotherapy, 55(5), 2325-2334 (2011)
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