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M7571

Sigma-Aldrich

MK-571 钠盐 水合物

≥95% (HPLC), powder, leukotriene D4 antagonist

别名:

5-（3-（2-（7-氯喹啉-2-基）乙烯基）苯基）-8-二甲基氨基甲酰-4,6-二硫杂辛酸 钠盐 水合物, L-660711

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About This Item

经验公式（希尔记法）:
C26H26ClN2NaO3S2 · xH2O
CAS号:
115103-85-0
分子量:
537.07 (anhydrous basis)
MDL编号:
MFCD11114392
UNSPSC代码:
51111800
PubChem化学物质编号:
329817910
NACRES:
NA.77

产品名称

MK-571 钠盐 水合物, ≥95% (HPLC)

质量水平

100

方案

≥95% (HPLC)

表单

powder

储存条件

desiccated

颜色

white to beige

溶解性

H2O: 15 mg/mL, clear

创始人

Merck & Co., Inc., Kenilworth, NJ, U.S.

运输

wet ice

储存温度

−20°C

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此商品
709207095371058
Rosetta(DE3) Competent Cells - Novagen Rosetta host strains are BL21 derivatives designed to enhance the expression of eukaryotic proteins that contain codons rarely used in E. coli.

70954

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Rosetta(DE3)pLacI Competent Cells - Novagen Rosetta strains are BL21 derivatives designed to enhance the expression of eukaryotic proteins that contain codons rarely used in E. coli. Contains the pLacI plasmid producing extra Lac repressor.

70920

Rosetta(DE3)pLacI Competent Cells - Novagen

Rosetta Competent Cells - Novagen Rosetta host strains are BL21 derivatives designed to enhance the expression of eukaryotic proteins that contain codons rarely used in E. coli.

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Rosetta Competent Cells - Novagen

RosettaBlue Competent Cells - Novagen RosettaBlue host strains are NovaBlue derivatives that combine high transformation efficiency and with enhanced expression of eukaryotic proteins that contain codons rarely used in E. coli.

71058

RosettaBlue Competent Cells - Novagen

technique(s)

microbiological culture: suitable

technique(s)

microbiological culture: suitable

technique(s)

microbiological culture: suitable

technique(s)

microbiological culture: suitable

growth mode

adherent or suspension

growth mode

adherent or suspension

growth mode

adherent or suspension

growth mode

adherent or suspension

morphology

rod shaped

morphology

rod shaped

morphology

rod shaped

morphology

rod shaped

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−70°C

shipped in

wet ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

应用

MK-571钠盐水合物已被用于：
  • 作为外排抑制剂，监测多药耐药蛋白（MRP）的功能并避免其他转运蛋白的重复[1]
  • 在多种多形性胶质母细胞瘤（GBM）细胞系中，体外评估其对细胞增殖和二维迁移的影响[2]
  • 作为多药抗性（MDR）转运蛋白抑制剂，研究其在卵巢癌细胞中的作用[3]
  • 作为ABCC1/2的特异性抑制剂，用于转运、毒性、流式细胞术和砷外排的研究[4]

生化/生理作用

MK 571 是一种强效选择性白三烯 D4 (LTD4) 拮抗剂和 ABCC 多药耐药蛋白 1 (MRP1) 抑制剂。半胱氨酰白三烯 (CysLTs)，LTC4、LTD4 和 LTE4 通过两种不同的 G 蛋白偶联受体介导其作用。LTD4 是 CysLT1 受体的首选配体，而 LTC4 和 LTD4 与 CysLT2 受体的亲和力大致相等。MK 571 是一种选择性、口服活性 CysLT1 受体拮抗剂。阻断 LTD4 而非 LTC4 与人和豚鼠肺膜的结合，Ki 值分别为 0.22 nM 和 2.1 nM。MK 571 可有效阻断重组人和小鼠 CysLT1 受体的 LTD4 活化，但对阻断重组人或鼠 CysLT2 受体的 LTC4 或 LTD4 活化无效。它可能抑制 MRP1，并已显示克服获得性砷耐受性。
MK-571 是一种强效选择性白三烯 D4 (LTD4) 拮抗剂和 ABCC 多药耐药蛋白 1 (MRP1) 抑制剂。

特点和优势

《受体分类和信号转导》手册的 GABAC受体页有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
该化合物是由Merck & Co., Inc., Kenilworth, NJ, U.S.开发的。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单， 请单击此处。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315,H319,H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    0000160616
    0000160616
    0000258144
    0000160618
    0000258144

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    Ravi S Kasinathan et al.
    PLoS neglected tropical diseases, 5(12), e1425-e1425 (2011-12-14)
    P-glycoprotein (Pgp) and multidrug resistance-associated proteins (MRPs) are ATP-dependent transporters involved in efflux of toxins and xenobiotics from cells. When overexpressed, these transporters can mediate multidrug resistance (MDR) in mammalian cells, and changes in Pgp expression and sequence are associated
    Winfried Neuhaus et al.
    Frontiers in cellular neuroscience, 8, 352-352 (2014-11-13)
    Stabilization of the blood-brain barrier during and after stroke can lead to less adverse outcome. For elucidation of underlying mechanisms and development of novel therapeutic strategies validated in vitro disease models of the blood-brain barrier could be very helpful. To
    The mechanisms of detoxification of As (III), dimethylarsinic acid (DMA) and As (V) in the microalga Chlorella vulgaris
    Munoz L P, et al.
    Aquatic Toxicology (Amsterdam, Netherlands), 175, 56-72 (2016)
    Joseph P Campanale et al.
    Development (Cambridge, England), 139(4), 783-792 (2012-01-26)
    ATP-binding cassette (ABC) transporters protect embryos and stem cells from mutagens and pump morphogens that control cell fate and migration. In this study, we measured dynamics of ABC transporter activity during formation of sea urchin embryonic cells necessary for the
    Hye-Sik Kong et al.
    Pharmaceutical research, 29(12), 3373-3383 (2012-07-28)
    The HDAC shuttling inhibitor, YK-4-272 functions by restricting nuclear shuttling of Class II HDACs. Pre-clinical investigations of YK-4-272 bioavailability, pharmacokinetics, in vivo toxicity and tumor growth inhibition were performed to determine its potential as an HDAC shuttling disruptor for use
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