推荐产品
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
tissue culture supernatant
抗体产品类型
primary antibodies
克隆
P3II-26, monoclonal
种属反应性
human
浓度
250 μg/mL
技术
immunocytochemistry: 1:20-1:50 using acetone-fixed cytospin preparations
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable (not suitable for human tissues)
immunohistochemistry (frozen sections): 1:20 using acetone-fixed sections
western blot: suitable
同位素/亚型
IgG2b
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... ABCB11(8647) , ABCB4(5244)
一般描述
多药耐药蛋白3（MDR3）又称ATP结合盒亚家族B成员4。在肝细胞中表达，由1279个氨基酸组成。编码它的基因位于人类染色体7q21.12上，由27个外显子组成。
特异性
与MDR3的内部表位反应。不与人MDR1 P-gp发生交叉反应。
免疫原
MDR3 P-gp（氨基酸629-692）GST融合蛋白。
生化/生理作用
多药耐药性蛋白3（MDR3）充当ATP依赖性输出物，并将磷脂，特别是磷脂酰胆碱（PC）转移到胆汁中。MDR3的功能障碍导致原发性胆汁中胆汁盐的过量，并进一步导致肝脏疾病。
外形
在含有0.7%牛血清白蛋白和0.1%叠氮化钠的无血清培养基中提供。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
未找到合适的产品？
试试我们的产品选型工具.
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Hao-Zhe Sun et al.
World journal of gastroenterology, 21(2), 699-703 (2015-01-17)
Genotyping is conclusive for the diagnosis of progressive familial intrahepatic cholestasis type 3 (PFIC3). Here we report a Chinese patient of PFIC3 with compound mutations in the ABCB4 gene. Liver biopsy was performed on a 17-year-old male patient with intrahepatic
Marianne Kluth et al.
The Journal of biological chemistry, 290(8), 4896-4907 (2014-12-24)
The human multidrug resistance protein 3 (MDR3/ABCB4) belongs to the ubiquitous family of ATP-binding cassette (ABC) transporters and is located in the canalicular membrane of hepatocytes. There it flops the phospholipids of the phosphatidylcholine (PC) family from the inner to
Steffen Kiehl et al.
Scientific reports, 4, 6899-6899 (2014-11-05)
Epigenetic silencing through promoter hypermethylation is an important hallmark for the inactivation of tumor-related genes in carcinogenesis. Here we identified the ATP-binding cassette sub-family B member 4 (ABCB4) as a novel epigenetically silenced target gene. We investigated the epigenetic regulation
Yu Zhao et al.
Journal of lipid research, 56(3), 644-652 (2015-01-21)
ABCB4, which is specifically expressed on the canalicular membrane of hepatocytes, exports phosphatidylcholine (PC) into bile. Because SM depletion increases cellular PC content and stimulates PC and cholesterol efflux by ABCA1, a key transporter involved in generation of HDL, we
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门